In the statistical analysis of endometriosis in our present and previous series, no significant geographical or racial peculiarities were noted. As in other parts of the world, the cases where the diagnosis was made prepreoperatively and th…
Danazol was administered to patients with endometriosis and infertility in a study designed to assess its therapeutic efficacy and side effects. Forty-six patients with endometriosis were treated with 300 mg or 400 mg/day of danazol for a m…
Endometriosis is often associated with infertility, which might be a consequence of intraperitoneal macrophage activation and various immunological events related to it. To determine what triggers macrophage activation and what immunologic …
In view of increasing incidence of adenomyosis and endometriosis reported in recent years, we evaluated the incidence of these disorders in a unique ultra-orthodox Jewish population over the past 20 years by reviewing 1,434 hysterectomy spe…
It has been reported that there exists a correlation between endometriosis and the luteal phase defect (LPD) as one of the determinants in infertility. In some theories, the hampered maturation of the corpus luteum is believed to be caused …
The social class distribution in 147 patients confirmed to have endometriosis at laparoscopy was done to see if the disease was associated with affluence. Two hundred and eighty-one patients confirmed not to have endometriosis was used as c…
The effects of a GnRH agonist and danazol on bone mineral content (BMC) in Japanese women with endometriosis were investigated. Nineteen women with laparoscopically confirmed endometriosis were treated with buserelin (900 micrograms/d admin…
To determine the main factors that affect the prognosis for conception in endometriosis-associated infertility, 99 infertile patients with laparoscopically confirmed endometriosis were classified according to the new TOP classification, whi…
A Japanese woman with severe abdominal pain underwent an emergent exploratory laparotomy. Intraperitoneal bleeding from the uterine serosal surface was observed, and a pathologic examination showed that the bleeding was caused by an exudati…
Thirty-four recurrent cases of 89 patients with ovarian cancer treated in our department between 1985 and 1989 were examined for changes in serum CA125 level. 1) Upon confirmation of recurrence, 17 patients were positive for CA125 and 15 we…
Progestogens are drugs which share the ability to stimulate the progesterone receptor, but differ in many other aspects. Some of their uses include the regulation of menstrual bleeding, protection of oestrogen-primed endometrium, contracept…
In order to investigate the effect of the local direct action of danazol upon endometriosis, intravaginal and intrauterine application were tried. A vaginal danazol ring containing 2 g to 3.5 g danazol not only reduced both dysmenorrhea and…
The mechanism of infertility in women with endometriosis is still largely unclear. It is thought that peritoneal macrophages increase in number in women with endometriosis and that the macrophages phagocytize sperm or the fertilized ovum, l…
Gamete intrafallopian transfer (GIFT) is increasingly accepted as a realistic alternative to in vitro fertilization (IVF), or intrauterine insemination (IUI) for treatment of non-tubal infertility. The lack of information on fertilization c…
Abstract In an effort to reduce undesirable bleeding during danazol treatment, we attempted to see any correlation between the frequency of bleeding and the starting period of danazol treatment during the menstrual cycle. We studied 57 wome…
Abstract A 22‐year‐old female presented with primary amenorrhoea, congenital absence of vagina and rudimentary horn of the uterus. Laparoscopic examination revealed rudimentary uterus with normal tubes and small ovaries. She had 46 XX karyo…
Abstract For a preoperative differentiation between leiomyomata uteri and adenomyosis, we measured serum levels of the antigen CA 125, which is specific to ovarian non‐mucinous epithelial carcinoma, in patients with benign gynecologic disea…
Abstract This is a retrospective analysis of 157 subfertile patients with mild endometriosis confirmed at laparoscopy. 80.3% of them were Chinese and the Malays and Indians accounted for 8.9% and 8.3% of the cases respectively. Most of the …
Abstract Two cases of catamenial pneumothorax treated with danazol, an isoxazole derivative of 17α‐ethinyl testosterone, are reported. The first patient, a 44‐year‐old woman who had had 31 attacks of spontaneous pneumothorax at the onset of…
Abstract The serum prolactin (PRL) levels of 34 cases of endometriosis, 26 cases of adeno‐m‐osis, 30 cases of functional d‐smenorrhea, and 9 patients with m‐oma uteri were measured b‐ radioimmunoassa‐. The incidence of h‐perprolactinemia (>…
Abstract Nine patients with pelvic endometriosis were treated with gestrinone in a dose of 2.5 mg twice weekl‐ for 6 to 7 months. All patients became anovulator‐ with sporadic episodes of painless uterine bleeding lasting various periods of…
Abstract During the period 1971–1980 a total of 1226 diagnostic laparoscopies were performed at the Department of Obstetrics and Gynecology of Turku University Central Hospital. In 591 patients the indication for laparoscopy was chronic pel…