Hormone Treatment Related Bone Mineral Content Changes in Japanese Women with Endometriosis

M Fukushima, Mineko Fukushima, Masaaki Shindo, M Shindo, Kôzô Satô, K Sato
Asia-Oceania journal of obstetrics and gynaecology · 1993 · vol. 19(3) , pp. 299–307 · doi:10.1111/j.1447-0756.1993.tb00389.x · PMID:8250765 · W2064588485
article OA: closed CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found that buserelin treatment significantly decreased lumbar bone mineral content in Japanese women with endometriosis, while danazol treatment resulted in a slight gain.

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Abstract

The effects of a GnRH agonist and danazol on bone mineral content (BMC) in Japanese women with endometriosis were investigated. Nineteen women with laparoscopically confirmed endometriosis were treated with buserelin (900 micrograms/d administered intranasally, 10 cases) or with danazol (400 mg/d p.o., 9 cases) for 6 months. Trabecular BMC of the 3rd lumbar vertebra was measured using quantitative computerized tomography before treatment, at the end of treatment and 6 months after treatment by the same radiologist who was not informed about the drug used. Serum estradiol and the biochemical parameters of bone metabolism were also measured. A significant decrease in BMC (10% on average; maximum 25.4%) was observed at the end of treatment with buserelin (p < 0.01) and this loss was only partially recovered 6 months after treatment. In the danazol group, however, a slight gain in BMC was observed. Buserelin suppressed serum estrogen levels much more than danazol did. Parameters of bone resorption tended to increase in the buserelin group. Because treatment with buserelin, but not with danazol, was always associated with a significant decrease in BMC at L3, repeated usage of buserelin may lead to cumulative bone loss in patients with endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Bone Density Buserelin Danazol Endometriosis Adult Bone Density Buserelin Danazol Endometriosis Endometriosis Female Humans Japan Middle Aged Single-Blind Method

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (24)

Cited by (7)

SciLite annotations

chemicals 12
mineral danazol mineral buserelin danazol estradiol danazol buserelin estrogen buserelin buserelin danazol

Source provenance

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