Therapeutic Effect and Side Effects of Danazol in Endometriosis

Y Nagata, Yukihiro Nagata, Genichi Nakamura, G Nakamura, M Kusuda
Asia-Oceania journal of obstetrics and gynaecology · 2010 · vol. 8(3) , pp. 229–236 · doi:10.1111/j.1447-0756.1982.tb00570.x · PMID:7150085 · W2114782221
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Danazol treatment for endometriosis resulted in high symptomatic improvement but limited physical regression, with a 44% pregnancy rate and 28% recurrence, and noted hepatocellular damage at higher doses.

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Abstract

Danazol was administered to patients with endometriosis and infertility in a study designed to assess its therapeutic efficacy and side effects. Forty-six patients with endometriosis were treated with 300 mg or 400 mg/day of danazol for a mean duration of 22 weeks. Although the symptomatic improvement rate was greater than 90%, the improvement in cul-de-sac nodularity was 47% and endometriomas did not regress during danazol therapy. The pregnancy rate and recurrence rate following this drug regimen were 44% and 28%, respectively. These rates were similar to those obtained in a comparable group of patients treated with a pseudopregnancy regimen. Mild hepatocellular damage was observed in 43% of patients taking 400 mg/day of danazol, necessitating discontinuation of medication in some instances. On reducing the dosage to 300 mg/day, however, the incidence of hepatocellular damage was lowered to almost the same level as with treatment with pseudo-pregnancy therapy. After completion of danazol therapy ovulation returned quickly in all instances, hepatocellular damage disappeared and serum levels of GOT and GPT were rapidly restored to normal.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Danazol Endometriosis Pregnadienes Adult Chemical and Drug Induced Liver Injury Danazol Danazol Endometriosis Female Follow-Up Studies Humans Infertility, Female Infertility, Female Pregnadienes Pregnancy Recurrence

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