Dosage aspects of danazol therapy in endometriosis: Short-term and long-term effectiveness

Biberoglu KO, K. Biberoğlu, K O Biberoglu, Behrman SJ, S J Behrman
American Journal of Obstetrics and Gynecology · 1981 · vol. 139(6) , pp. 645–654 · doi:10.1016/0002-9378(81)90478-6 · PMID:6452062 · W1876522572
article OA: closed CC0 ⤵ 211 in-corpus citations
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This paper investigates the effectiveness of various danazol dosages for treating endometriosis over both short and long durations.

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Abstract

The use of danazol (Danocrine) appears to be the most effective medical form of therapy for endometriosis. A double-blind study on 32 patients with laparoscopically proved pelvic endometriosis was designed to evaluate the immediate short-term and long-term effectiveness of daily dosages of danazol (100, 200, 400, and 600 mg) on the amelioration of the disease, with the use of posttreatment surgical findings and symptomatic changes. The American Fertility Society classification based on a point system was used. The clinical and surgical improvement rates varied from 75% to 85% and 50% to 70%, respectively. Ovarian endometriomas of even 1 cm in size generally do not respond to danazol. The pregnancy rate was 45%. We have demonstrated that lower than maximum doses of danazol produce similar beneficial effects in the treatment. With the low dosages, we did not achieve freedom from side-effects. The average symptomatic recurrence rate was 36%, with a mean duration of 19 months of follow-up, and was dose dependent.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Pelvic Neoplasms Pregnadienes Adult Body Weight Body Weight Danazol Danazol Danazol Double-Blind Method Endometriosis Endometriosis Female Follow-Up Studies Humans Laparoscopy Menstruation Menstruation Pelvic Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (50)

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