Laparoscopic treatment of deep endometriosis with a diode laser: our experience

Stefano Angioni, Luigi Nappi, Felice Sorrentino, Michele Peiretti, Aris Daniilidis, Angelos Daniilidis, Alessandro Pontis, Andrea Tinelli, Raffaele Tinelli, Maurizio Nicola D'Alterio, Maurizio Nicola D’Alterio
Archives of gynecology and obstetrics · 2021 · vol. 304(5) , pp. 1221–1231 · doi:10.1007/s00404-021-06154-z · PMID:34448038 · PMC8490256 · W3194774659
article OA: gold CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Laparoscopic diode laser treatment of deep endometriosis in 50 patients demonstrated feasibility, safety, and significant improvements in pain and quality of life within 12 months.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This double-center retrospective study evaluated feasibility, safety, and effectiveness of laparoscopic excision of deep endometriosis using a Leonardo DUAL 45 diode laser (980/1470 nm) in 50 women aged 18–45 with histologically confirmed deep endometriosis, undergoing surgery between November 2017 and March 2019 and having at least 12 months of follow-up. Using medical record data, the authors assessed operative parameters and changes in pain (modified Biberoglu and Behrman scale) and quality of life at 3-, 6-, and 12-month visits, with surgery performed for chronic pelvic pain and/or infertility-related indications. They reported no intraoperative or early (within 30 days) complications, median operative time of 147 minutes, discharge within about 3 days on average, and significant improvement in pain and quality of life at follow-up (p < 0.01), while explicitly noting the need for randomized trials to better confirm efficacy, recurrence, and pregnancy outcomes. This paper is centrally about endometriosis — it evaluates laparoscopic diode laser treatment outcomes for deep endometriosis in symptomatic patients.

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Abstract

PURPOSE: To evaluate whether laparoscopic treatment with a diode laser is feasible, safe, and effective in symptomatic patients affected by deep endometriosis (DE). METHODS: This retrospective study was performed using medical record data. The surgical reports, chronic pain scores, and quality of life (QoL) data were evaluated for 50 patients who had undergone laparoscopic surgery between November 2017 and March 2019 at two university hospitals (Monserrato (CA) and Foggia, Italy). Indications for surgery were chronic pelvic pain and/or infertility in patients who wished to conceive spontaneously. Endometriosis lesions/nodules were excised using a diode laser (Leonardo®, Biolitec® DUAL 45) that can combine 980 and 1470 nm wavelengths transmitted through a 1000 µm conical optical fibre. RESULTS: . The mean operation time was 147 min (range 106-190). No intraoperative or early complications (< 30 days) were reported. All patients left the hospital, on average, within 3 days (range 2-9 days) after surgery. A significant improvement in pain was observed at the 3-, 6-, and 12-month follow-up (p < 0.01) in all patients. Moreover, patients reported a significant QoL improvement at the 12-month follow-up. CONCLUSION: The diode laser confirmed its feasibility and safety for treating endometriosis. During the shaving surgical procedure, the diode laser system ensures a safe and effective laparoscopic dissection of deep endometriotic lesions. Further comprehensive randomized trials are necessary to confirm these preliminary data in terms of efficacy, recurrence rates, and pregnancy outcomes.

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Condition tags

endometriosischronic_pelvic_paininfertility

MeSH descriptors

Endometriosis Endometriosis Laparoscopy Rectal Diseases Rectal Diseases Adult Female Humans Lasers, Semiconductor Lasers, Semiconductor Pregnancy Quality of Life Retrospective Studies Treatment Outcome Young Adult

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