The effects of danazol on gonadotropins and steroid blood levels in normal and anovulatory women.
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Danazol did not suppress gonadotropins and steroids in normal women but induced ovulation in two anovulatory patients and one normal subject, while relieving hot flushes in postmenopausal patients.
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Abstract
The effect of Danazol, a new gonadotropin inhibitor, was examined in four categories of patients. (1) Ten normal women medicated orally with Danazol, 800 mg. daily for 91 days, showed no depression of serum LH, estrone, estradiol, or progesterone below control, second-day levels. The serum FSH was slightly depressed; (2) Two anovulatory patients having elevated serum LH values were treated with Danazol, 400 to 800 mg. daily, for 1 to 3 days at midcycle. One patient repeatedly showed a temperature rise and LH flood within 24 hours of initial medication. Both had menstrual periods 7 to 9 days later. (3) Two normal midcycle ovulators were treated with 400 and 800 mg; of Danazol, respectively, for 1 day in the midfollicular phase and one apparently ovulated promptly prematurely. (4) Two patients having severe hot flushes following surgical menopause were treated with Danazol, 800 mg; daily, without reducing FSH or LH but with disappearance of hot flushes.
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Cited by (39)
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- Use of Mifepristone to Treat Endometriosis: A Review of Clinical Trials and Trial-Like Studies Conducted in China 2010
- Danazol regulates the functions of normal human endometrial stromal cell subpopulations by modifying endometrial cytokine networks 2009
- Emerging drugs for endometriosis 2008
- Measurement of serum and peritoneal fluid LH concentrations as a diagnostic tool for human endometriosis 2001
- Altered uterine artery blood flow impedance after danazol therapy: possible mode of action in dysfunctional uterine bleeding 1999
- Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology 1998
- Elimination of ovulation and menstrual cyclicity (with danazol) improves dysphoric premenstrual syndromes. 1991
- Elimination of ovulation and menstrual cyclicity (with danazol) improves dysphoric premenstrual syndromes 1991
- Cyclical mastopathy: A critical review of therapy 1988
- A clinical trial using danazol for the treatment of premenstrual tension 1987
- Endocrine consequences of danazol treatment in menorrhagia 1986
- Danazol inhibits steroidogenesis by the human ovary in vivo 1986
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1985
- Conservative treatment of endometriosis externa: the effects of danazol therapy 1985
- Management of pelvic endometriosis with low-dose danazol 1985
- Effect of danazol on serum concentrations of pituitary gonadotropins in postmenopausal women 1984
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1984
- Effects of danazol on pulsatile gonadotropin patterns and on serum estradiol levels in normally cycling women 1983
- The effect of danazol on gonadotropin secretion during the follicular phase of the menstrual cycle 1983
- Conservative treatment of endometriosis externa: the effects of danazol therapy 1983
- Dynamic tests of hypothalamic and pituitary function in women treated with danazol 1982
- Effects of danazol on gonadal steroidogenesis in patients with a complete form of testicular feminization 1982
- Hormonal and Surgical Management of Pelvic Endometriosis 1982
- Dosage aspects of danazol therapy in endometriosis: Short-term and long-term effectiveness 1981
- Management of Pelvic Endometriosis with Low-Dose Danazol 1981
- Treatment of pulmonary endometriosis with danazol 1981
- Cholesterol, High Density Lipoprotein and Danazol 1981
- Pharmacology and Pharmacokinetics of Danazol 1980
- EFFECT OF DANAZOL ON SERUM GONADOTROPHINS AND STEROID HORMONE CONCENTRATIONS IN WOMEN WITH MENORRHAGIA 1980
- Competitive inhibition by Danazol of oestradiol binding to rabbit and ovine uterine oestradiol receptor 1980
- Inhibition of Adrenal Steroidogenesis by Danazol in Vivo 1980
- Danazol in the Treatment of Gynaecomastia 1980
- Danazol—A Steroid with a Unique Combination of Actions 1979
- Effects of Danazol on gonadotropin secretion after ovariectomy in rats 1978
- Danazol effects on gowadotrop in basal levels and pituitary responsiveness to lh-rn in immature male rats 1978
- The Effect of Danazol on Anterior Pituitary Function 1977
- Progestational activity of Danazol in the human female subject 1976
- HOW DOES DANAZOL WORK? 1976
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