Cholesterol, High Density Lipoprotein and Danazol
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Danazol treatment for endometriosis reduced high density lipoprotein cholesterol levels and elevated beta-lipoprotein, with these changes reversing post-treatment.
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Abstract
The synthetic steroid, danazol [17 alpha-pregna-2,4-dien-20-yno-(2,3,d)isoxazol-17-ol], is used widely for the treatment of endometriosis. In nine subjects studied over a 6-month course of treatment and for 5 months subsequently, plasma high density lipoprotein cholesterol (HDL-C) levels fell during treatment (P less than 0.001) and were restored to pretreatment levels within 3-5 months after treatment ceased. In these patients, total cholesterol did not increase significantly, yet the depressed levels of HDL-C apparently masked an increase in the total cholesterol in the remaining lipoprotein classes (P less than 0.01). Triglyceride levels were not affected significantly over the course of the treatment. Lipoprotein electrophoresis indicated an elevated beta-lipoprotein band in the subjects using danazol. All effects of danazol on plasma levels of cholesterol and HDL-C were reversed within 3-5 months after the cessation of treatment.
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References (17)
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Cited by (15)
- A Randomized, Parallel, Comparative Study of the Efficacy and Safety of Nafarelin Versus Danazol in the Treatment of Endometriosis in Taiwan 2005
- Danazol in the Treatment of Menorrhagia: The Effect of a 1 Month Induction Dose (200 mg) and 2 Month's Maintenance Therapy (200 mg, 100 mg, 50 mg or placebo) 1992
- Medical treatment of mild endometriosis associated with infertility 1991
- Comparison of the pharmacology of nafarelin and danazol 1990
- Danazol therapy renders red cells resistant to osmotic lysis <sup>1</sup> 1989
- A comparison of the effects of Buserelin versus danazol on plasma lipoproteins during treatment of pelvic endometriosis 1988
- Cyclical mastopathy: A critical review of therapy 1988
- Lipid metabolic changes during hormonal treatment of endometriosis 1988
- Endometriosis 1987
- Lipoprotein changes during treatment of pelvic endometriosis with medroxyprogesterone acetate 1986
- Lipoprotein changes during treatment of pelvic endometriosis with medroxyprogesterone acetate. 1986
- Treatment of Dysfunctional Uterine Bleeding with Danazol 1985
- Profound alterations of the lipoprotein metabolism during danazol treatment in premenopausal women 1984
- Plasma lipoproteins during and after danazol treatment 1984
- Effects of danazol on plasma lipid and lipoprotein levels in healthy women and in women with endometriosis 1983
Source provenance
- europepmc
- last seen: 2026-06-16T06:07:01.518242+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:10:06.101301+00:00
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