Plasma lipoproteins during and after danazol treatment

L Fåhraeus, Lars Fåhraeus, Ulf Larsson‐Cohn, U Larsson-Cohn, S Ljungberg, Sten Ljungberg, Lars Wallentin, L Wallentin
Acta obstetricia et gynecologica Scandinavica. Supplement · 1984 · vol. 63(S123) , pp. 133–135 · doi:10.3109/00016348409157000 · PMID:6594004 · W2014097786
article OA: closed CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Danazol treatment for endometriosis significantly decreased HDL cholesterol while increasing LDL cholesterol and triglycerides, with lipoprotein levels returning to baseline eight weeks after cessation.

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Abstract

Twelve women with pelvic endometriosis were treated with danazol, at a dose of 200 mg three times daily, over a 24-week period. The concentrations of cholesterol and triglycerides were determined in plasma and in the lipoprotein fractions. After only 2 weeks the mean high density lipoprotein (HDL) cholesterol had already decreased by 49% and 6 weeks later the reduction was 59%. The low density lipoprotein (LDL) cholesterol concentration increased by 14% after 2 weeks and by 34% after 8 weeks. The triglycerides increased by 20% after 2 weeks. Eight weeks after cessation of treatment the lipoprotein fractions had returned to the pretreatment levels.

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Condition tags

endometriosis

MeSH descriptors

Danazol Lipoproteins, HDL Lipoproteins, LDL Pregnadienes Danazol Endometriosis Endometriosis Female Humans Lipoproteins, HDL Lipoproteins, LDL Pregnadienes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (13)

Cited by (4)

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License: CC0 · commercial use OK