Acta obstetricia et gynecologica Scandinavica. Supplement

Danazol, a weakly androgenic, heterocyclic compound with anabolic properties, is used primarily in the treatment of endometriosis and other gynecological complaints. Early reports indicated that the drug had little effect on plasma lipid (c…

The American Fertility Society (AFS) classification for endometriosis is a widely-used system for categorizing the severity of pelvic endometriosis. Although this classification represents a detailed description of the location and extent o…

The non-surgical treatment of endometriosis involves hormone therapy that either affects the lesions directly, or indirectly inhibits endometrial proliferation and induces atrophy through estrogen deprivation, or through a combination of th…

The current management of endometriosis includes expectant, medical, surgical and combined therapies and the selection is based on the staging of the disease proposed by the American Fertility Society (AFS). This approach, however, has prov…

It is well recognized that cell-mediated immune responses contribute to the elimination of foreign antigens and cells from the invading organism. It is also likely that the immune system can recognize and eliminate altered or misplaced auto…

In many ways endometriosis represents yet another form of unexplained infertility. The disease is clearly associated with a decrease in fecundity and while in advanced stages of the condition this infertility can be attributed to tubal fact…

CA 125 is an antigenic determinant on a high molecular weight glycoprotein. A monoclonal antibody has been produced which recognizes this, and allows us to measure the expression of CA 125 in serum. Tissue distribution of the CA 125 determi…

Concentrations of cytosol estrogen (ERc) and progestin (PRc) receptors and the activities of 17 beta-hydroxysteroid dehydrogenase (17-HSD) were measured in 80 untreated and 23 danazol-treated endometriotic tissue specimens. The results were…

Previous studies have demonstrated a hereditary tendency to develop endometriosis and the incidence of the disease varies in different ethnic groups. The genetic background to these differences has not been clearly explained. The present in…

A histochemical method for the detection of steroid-binding sites in very small tissue specimens was evaluated. Competitive binding experiments proved the method to be sufficiently specific. When applied to endometrium and endometriotic tis…

The influence of danazol treatment on uterine activity was studied by means of repeated intra-uterine pressure recordings in two women with laparoscopically diagnosed endometriosis. During a control cycle the women had normal plasma levels …

To study peritoneal fluid (PF) prostaglandin (PG) in infertile women, 6-keto-PGF1 alpha (a breakdown product of prostacyclin) and thromboxane B2 (T X B2) (a metabolite of T X A2) were assayed with radio-immunoassays from PF samples collecte…

Endometriosis frequently presents diagnostic problems. Its symptoms and findings are non-specific and there are no non-invasive diagnostic tests. Laparoscopy is the most valuable diagnostic tool for use in a patient with endometriosis. Lapa…

Twelve women with pelvic endometriosis were treated with danazol, at a dose of 200 mg three times daily, over a 24-week period. The concentrations of cholesterol and triglycerides were determined in plasma and in the lipoprotein fractions. …

A total of 215 infertile patients with endometriosis verified at least laparoscopically were treated between 1977 and 1982 by conservative surgery alone (N = 90), or with danazol, 600 mg daily and most often for 6 months, either alone (N = …

Abstract. One hundred and sixteen patients with laparosco‐pically confirmed primary or recurrent endometriosis were treated with danazol, either 600 mg daily for 4 months (group A, n = 76) or 600 mg daily for the first 2 months, followed by…

The synthetic steroid danazol has rapidly become the drug most commonly used in the hormonal treatment of endometriosis and its clinical and endocrine properties in women have been investigated extensively. However, little is known about th…

Six infertile patients with vaginal endometriosis were treated with danazol at 600 mg daily for 6 months. Three patients had previously undergone surgery for pelvic endometriosis. After 4 months of danazol treatment there was a clear reduct…