Profound alterations of the lipoprotein metabolism during danazol treatment in premenopausal women

Lars Fåhraeus, L Fåhraeus, Fåhraeus L, U Larsson-Cohn, Ulf Larsson‐Cohn, Larsson-Cohn U, Sten Ljungberg, S Ljungberg, Ljungberg S, Wallentin L, Lars Wallentin, L Wallentin
Fertility and Sterility · 1984 · vol. 42(1) , pp. 52–57 · doi:10.1016/s0015-0282(16)47957-4 · PMID:6724013 · W2419075596
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Danazol treatment in premenopausal women with endometriosis significantly reduced HDL cholesterol and increased LDL cholesterol, with decreased LCAT rates and returned to baseline after cessation.

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Abstract

Twelve women with pelvic endometriosis were treated with 600 mg of danazol daily for 24 weeks. The molar and fractional lecithin:cholesterol acyl transfer (LCAT) rates and the concentrations of cholesterol, phospholipids, and triglycerides were determined in plasma and in the very low-density lipoprotein, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and HDL2 and HDL3 fractions before, during, and after the medication. After 2 weeks the HDL, HDL2, and HDL3 cholesterol concentrations were reduced by 49%, 73%, and 29%, respectively, while the LDL level was increased by 14%. The molar and fractional LCAT rates decreased during treatment, and these reduced LCAT rates are consistent with a reduced fractional LDL removal. Within 8 weeks after cessation of medication, all parameters had returned to the pretreatment levels.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Lipoproteins Pelvic Neoplasms Pregnadienes Adult Cholesterol Cholesterol Danazol Danazol Endometriosis Endometriosis Female Humans Lipoproteins Lipoproteins, HDL Lipoproteins, HDL Lipoproteins, LDL Lipoproteins, LDL Lipoproteins, VLDL

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Cited by (24)

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