EFFECT OF DANAZOL ON SERUM GONADOTROPHINS AND STEROID HORMONE CONCENTRATIONS IN WOMEN WITH MENORRHAGIA

T. H. K. Chimbira, Anne B. M. Anderson, E. D. Cope, A. C. Turnbull
In: BJOG: An International Journal of Obstetrics & Gynaecology · 1980 · vol. 87(4) , pp. 330–336 · doi:10.1111/j.1471-0528.1980.tb04550.x · PMID:7426503 · W2085751950
article OA: closed CC0 ⤵ 16 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Danazol treatment in women with menorrhagia suppressed ovulation, reduced estradiol levels, but did not affect androstenedione, dehydroepiandrosterone, or its sulfate.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

In 13 ovulatory women with objective evidence of menorrhagia (menstrual blood loss greater than 80 ml), danazol 400 mg given daily for 12 weeks suppressed ovulation as shown by absence of gonadotrophin peaks, low serum progesterone levels and flat basal body temperature recordings. Serum concentrations of luteinising hormone and follicle stimulating hormone were within the range found during the normal menstrual cycle but oestradiol concentrations tended to fall, reaching levels less than 100 pmol/l in some patients. Danazol treatment had no effect on levels of androstenedione or dehydroepiandrosterone and its sulphate. The presence or absence of cyclical bleeding on treatment, and the measured blood loss was unrelated to circulating oestradiol levels.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (18)

Cited by (16)

Source provenance

openalex
last seen: 2026-05-10T11:13:26.172743+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0 · commercial use OK