Effects of Danazol on Pituitary Gonadotrophins in Post‐Menopausal Women

Ian S. Fraser, G. D. Thorburn
In: Australian and New Zealand Journal of Obstetrics and Gynaecology · 1978 · vol. 18(4) , pp. 247–249 · doi:10.1111/j.1479-828x.1978.tb00063.x · PMID:284768 · W2013625413
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

Danazol treatment in postmenopausal women caused a slight but significant decrease in FSH in three of four subjects and an LH decrease in only one, suggesting other mechanisms may contribute to its effects.

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Abstract

Multiple sampling was carried out in 4 postmenopausal women for measurement of LH and FSH before and at the end of a 1-week treatment period with Danazol (400 mg daily). A small but significant depression of FSH was found in 3 of 4 subjects, while a significant depression of LH was only seen in 1 subject. In view of the very modest gonadotrophin suppression demonstrated in these women it is possible that Danazol also exerts its profound and sometimes rapid effects through inhibition of positive oestrogen feedback and by direct actions on the ovaries and endometrium.

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