The effects of danazol on the pituitary-ovarian axis in the Rhesus monkey (Macaca mulatta)

G. Jenkin, Ian S. Fraser, I S Fraser, J. R. G. Challis, J R Challis, H. Elvidge, G. D. Thorburn
The Journal of international medical research · 1977 · vol. 5 Suppl 3 , pp. 44–56 · PMID:410687 · W2304972881
Lab / animal OA: closed CC0 ⤵ 6 in-corpus citations
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Danazol administered to rhesus monkeys during the menstrual cycle delayed ovulation, depressed progesterone secretion, and showed varying sensitivity depending on the treatment phase and season.

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Abstract

The effects of danazol an antiogonadotropin derivative of ethisterone on the pituitary and ovarian function in the rhesus monkey were determined. Monkeys were administered danazol (30 mg/kg) from either Days 1-9 (Group 1 4 monkeys) 3-20 (Group 2 9 monkeys) or 10-20 (Group 3 2 monkeys) of the menstrual cycle. A 4th group of monkeys were treated with 80 mg/kg danazol on Days 1-8 plus an injection of either 50 mcg thyrotrophin releasing hormone luteinizing hormone-releasing hormone (100 mcg) or estradiol benzoate (EB; 250 mcg) on Day 4 of control and treatment cycles during the nonbreeding season. Danazol delayed ovulation in Group 1 animals. It caused a marked depression of progesterone secretion in Groups 1 and 3. Administration during the follicular phase of the cycle had no effect either on the time of ovulation or the luteal phase. In preliminary experiments with Group 4 it is suggested that the hypothalamo-pituitary-ovarian axis may be more sensitive to danazol in the anovular months than in the winter breeding season.

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MeSH descriptors

Danazol Ovary Pituitary Gland Pregnadienes Animals Danazol Danazol Danazol Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Haplorhini Luteinizing Hormone Luteinizing Hormone Macaca mulatta Menstruation Menstruation Ovary Pituitary Gland Pregnadienes

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