Peripheral androgen levels in danazol-treated premenopausal women

K Carlström, Kjell Carlström, Carlström K, A Döberl, Döberl A, Anton Döberl, Rannevik G, G Rannevik, Gunnar Rannevik
Fertility and sterility · 1983 · vol. 39(4) , pp. 499–504 · doi:10.1016/s0015-0282(16)46940-2 · PMID:6219898 · W2416842524
article OA: closed CC0 ⤵ 8 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study investigated the impact of danazol treatment on peripheral androgen levels in premenopausal women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Eighteen normally menstruating women with endometriosis were treated with 600 mg of danazol daily for 6 months. Blood samples were taken before and after 2, 4, 8, 12, and 16 weeks of treatment and were analyzed for plasma dehydroepiandrosterone sulfate (DHEA-S), dehydroepiandrosterone (DHEA), and testosterone (T) and for serum alanine aminotransferase (ALAT), albumin, creatinine, potassium, and sodium. The basal values of all parameters studied were well within normal reference limits. DHEA-S was significantly increased at 2, 4, and 8 weeks, and DHEA significantly decreased at 8 and 12 weeks of treatment. The ratio between DHEA and DHEA-S was significantly decreased at weeks 4, 8, 12, and 16. T was significantly decreased during the whole period of observation. ALAT was significantly increased at weeks 4, 8, 12, and 16. A slight but significant increase was observed for creatinine and potassium, while no changes were observed for albumin and sodium. Of the two major androgen sources, the adrenal cortex appears to be relatively unaffected; whereas the ovary may be affected to a minor degree. Therefore, it seems likely that the changes observed in DHEA and DHEA-S may be due to minor alterations in renal and hepatic turnover rather than an effect on adrenal steroidogenesis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Androgens Danazol Pregnadienes Adult Alanine Transaminase Alanine Transaminase Androgens Danazol Danazol Dehydroepiandrosterone Dehydroepiandrosterone Dehydroepiandrosterone Dehydroepiandrosterone Sulfate Endometriosis Endometriosis Endometriosis Female Humans Middle Aged Pregnadienes

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (7)

Source provenance

europepmc
last seen: 2026-08-21T06:14:13.963979+00:00
openalex
last seen: 2026-05-13T18:37:28.025090+00:00
pubmed
last seen: 2026-05-13T22:09:55.985569+00:00
unpaywall
last seen: 2026-08-21T06:37:11.537704+00:00
License: CC0 · commercial use OK