Danazol: endocrine and endometrial effects.
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Danazol therapy at 200-800 mg daily did not alter LH-FSH, prolactin, TSH, TBG, thyroxine, cortisol, or androstenedione but modestly decreased estrogens, increased androgens, and caused endometrial atrophy.
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Abstract
The mechanisms of action of danazol are unknown and the alteration of normal human endocrine values during danazol therapy is controversial. Twenty patients were given 200-800 mg of danazol daily. Control and treatment blood serum samples were obtained with serial endometrial biopsies and basal body temperatures. LH-FSH basal levels, prolactin, TSH, TBG, thyroxine, cortisol, and androstenedione were not changed by either dosage or duration of danazol therapy. Estrone and estradiol serum levels were modestly decreased and were not dose-dependent. There were significant dose related increases in serum testosterone and DHEA-S. Endometrial atrophy occurred at all dose levels.
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Cited by (28)
- Endogenous Steroid Hormone Concentrations and Risk of Endometriosis in Nurses’ Health Study II 2022
- Androgens Upregulate Endometrial Epithelial Progesterone Receptor Expression: Potential Implications for Endometriosis 2017
- Endometriosis for the Colorectal Surgeon 2010
- Danazol regulates the functions of normal human endometrial stromal cell subpopulations by modifying endometrial cytokine networks 2009
- Effects of Hormones 2005
- Modern Medical Therapy of Endometriosis 2004
- The Influence of Hormones and Pharmaceutical Agents on DHEA and DHEA‐S Concentrations: A Review of Clinical Studies 2002
- Endometriosis and Pelvic Pain 1998
- Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology 1998
- Danazol versus a gonadotropin-releasing hormone agonist as preoperative preparation for hysteroscopic metroplasty 1996
- Vaginal patterns during danazol and buserelin acetate therapy for endometriosis: structural and ultrastructural study 1993
- Adrenal Steroids in Serum during Danazol Therapy, Taking into Account Cross-Reactions between Danazol Metabolites and Serum Androgens. 1993
- Endometrial patterns during therapy with danazol or gestrinone for endometriosis: Structural and ultrastructural study 1992
- Provocative tests of prolactin before, during and after long-term danazol treatment in patients with endometriosis 1992
- Tissue Factors Influencing Growth and Maintenance of Endometriosis<sup>a</sup> 1991
- Danazol stimulates the release of follicle-stimulating hormone and inhibits the release of prolactin in vitro studies on rat pituitary cell cultures 1989
- Genital Bleeding during the Administration of Danazol 1988
- DOSAGE‐RELATED EFFECTS OF DANAZOL ON SEX HORMONE BINDING GLOBULIN AND FREE AND TOTAL ANDROGEN LEVELS 1986
- Danazol inhibits steroidogenesis by the human ovary in vivo 1986
- Human endometrium transplanted into nude mice. Histologic effects of various steroid hormones. 1985
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1985
- Cytosol estrogen and progestin receptor concentrations and 17β‐hydroxysteroid dehydrogenase activities in the endometrium and endometriotic tissue 1984
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1984
- Short‐term effects of danazol on endometrial histology 1984
- Effects of ethinylestradiol and danazol on embryo survival and implantation in mated beagle bitches. 1983
- Free testosterone levels during danazol therapy 1983
- Peripheral androgen levels in danazol-treated premenopausal women 1983
- Danazol and gestagen displacement of testosterone and influence on sex-hormone-binding globulin capacity 1982
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