Danazol versus a gonadotropin-releasing hormone agonist as preoperative preparation for hysteroscopic metroplasty

Luigi Fedele, Stefano Bianchi, L. Gruft, G. Bigatti, Mauro Busacca
In: Fertility and Sterility · 1996 · vol. 65(1) , pp. 186–188 · doi:10.1016/s0015-0282(16)58049-2 · PMID:8557138 · W2343470492
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This study compared the effectiveness of danazol versus a GnRH agonist in preparing patients for hysteroscopic metroplasty, assessing outcomes related to uterine septum reduction and patient recovery.

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Abstract

ObjectiveTo compare the efficacy of danazol and a GnRH agonist as preoperative preparation for hysteroscopic metroplasty in women with septate uterus.DesignProspective randomized clinical study.SettingTertiary care center.PatientsThirty patients with septate uterus.InterventionsThe patients were randomized to treatment with danazol 600 mg/d for 2 to 4 weeks (n = 15) or with leuprolide acetate depot 3.75 mg for 2 months (n = 15) as preoperative therapy for hysteroscopic metroplasty.Main outcome measuresAt the intervention the hysteroscopist evaluated difficulty in dilation of the cervical canal, presence of endometrial fragments, bleeding, difficulty in maneuvering the resectoscope, and operating time.ResultsBoth the treatments were well tolerated. Metroplasty was simpler overall in the danazol group and also faster in introducing the resectoscope through the cervical canal and maneuvering it in the uterine cavity were both easier. Bleeding was modest in both groups and the anatomic outcome of the operation was similar.ConclusionShort preoperative preparation with danazol results in favorable operating conditions at limited costs with minimal side effects.

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