Gestrinone versus danazol as preoperative treatment for hysteroscopic surgery: a prospective, randomized evaluation

Onofrio Triolo, Antonio De Vivo, Vincenzo Di Benedetto, Salvatore Falcone, F Antico
In: Fertility and Sterility · 2006 · vol. 85(4) , pp. 1027–1031 · doi:10.1016/j.fertnstert.2005.09.034 · PMID:16580390 · W2042848684
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This prospective, randomized study evaluated gestrinone and danazol as preoperative treatments for hysteroscopic surgery.

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Abstract

ObjectiveTo compare danazol and gestrinone treatment as preoperative endometrial preparation for operative hysteroscopy.DesignProspective, randomized clinical study.SettingUniversity department of gynecological, obstetrical sciences and reproductive medicine.Patient(s)One hundred thirty-five patients with endouterine pathologies (endometrial polyps, submucous myoma, septate uterus).Intervention(s)Patients pretreated with gestrinone (n = 68) and with danazol (n = 67) underwent operative hysteroscopy.Main outcome measure(s)Endometrial response to the medical pretreatment, side effects, procedure time, intraoperative bleeding, infusion volume, patient satisfaction.Result(s)Side effects were infrequent in both groups, though the patients' personal satisfaction was in favor of gestrinone. The rate of endometrial response was higher for the gestrinone group (97.1% vs. 83.6%). Operative time (mean +/- SD) was 12 +/- 1.8 and 15.2 +/- 1.9 minutes for the gestrinone and danazol groups, respectively. The gestrinone group showed a lower incidence of moderate bleeding (3% vs. 22.4%) and a lower infusion volume (2,100 +/- 200 mL vs. 2,400 +/- 250 mL). Regarding cervical dilatation time, no significant difference was found between the two groups (1.6 +/- 0.3 minutes vs. 1.5 +/- 0.4 minutes).Conclusion(s)Both treatments are good ways to prepare the endometrium for operative hysteroscopy. However, the data suggest that gestrinone pretreatment is preferable to danazol.

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