Free testosterone levels during danazol therapy

B Nilsson, Nilsson B, Bo Nilsson, R Södergård, Södergård R, M.‐G. Damber, Damber MG, M G Damber, J E Damber, Damber JE, Jan‐Erik Damber, B von Schoultz, Bo von Schoultz, von Schoultz B
Fertility and Sterility · 1983 · vol. 39(4) , pp. 505–509 · doi:10.1016/s0015-0282(16)46941-4 · PMID:6682051 · W131734952
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This paper reports on the levels of free testosterone observed in individuals undergoing danazol therapy.

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Abstract

Danazol is a testosterone (T) derivative widely used in the clinical treatment of endometriosis. Its mechanism of action is poorly understood, but is side effects are mainly androgenic. Previously it was demonstrated that danazol can displace T from sex-hormone-binding globulin (SHBG). The binding properties of danazol to SHBG and albumin were studied with the use of labeled danazol in an aqueous two-phase equilibrium partition system. Levels of total T, SHBG, and albumin were measured in 16 women undergoing danazol treatment for endometriosis. Thereafter, free and protein-bound T levels were calculated. A marked rise in free T was found during danazol therapy as compared with pretreatment levels. The data suggest that many of the effects of danazol could be explained by increased levels of free T during treatment.

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Condition tags

endometriosis

MeSH descriptors

Danazol Pregnadienes Testosterone Danazol Danazol Endometriosis Endometriosis Endometriosis Female Genital Neoplasms, Female Genital Neoplasms, Female Genital Neoplasms, Female Humans Pregnadienes Radioimmunoassay Serum Albumin Serum Albumin Sex Hormone-Binding Globulin Sex Hormone-Binding Globulin Testosterone

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (22)

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License: CC0 · commercial use OK