Effects of danazol in the treatment of severe endometriosis.
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Danazol treatment of 20 endometriosis patients for six months improved most symptoms, with reversible biochemical changes, and three conceptions occurred post-treatment.
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Abstract
Twenty patients, mostly with severe endometriosis and infertility, were treated with danazol 600 mg daily for six months. Clinical investigation and laboratory tests were done monthly. During treatment most clinical findings and symptoms of endometriosis disappeared within 2 to 3 months, but rectocervical induration and rectocervical pain decreased more slowly. During the 10 months follow-up after discontinuation of danazol, dysmenorrhoea recurred most commonly of all symptoms, but not to the same degree as before treatment and the patients were mainly satisfied. Gonadotrophin and prolactin levels did not alter significantly during treatment. Serum oestradiol and progesterone values were low during the danazol course. Testosterone values increased because of cross-reaction with danazol metabolites in the testosterone assay. Serum transaminase, creatinine, haemoglobin and blood platelet concentrations increased on average, but the changes were reversible. Three conceptions occurred during the period of study.
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Cited by (20)
- Management of Stage III and IV endometriosis: a 10-year experience 1994
- The Detection of Danazol and Its Significance in Doping Analysis 1992
- Endometriosis and infertility 1990
- Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate 1990
- Efficacy Of Gonadotropin‐Releasing Hormone Agonist (Buserelin) in The Treatment Of Endometriosis 1989
- Genital Bleeding during the Administration of Danazol 1988
- Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis 1987
- Placebo-controlled comparison of danazol and high-dose medroxypro-gesterone acetate in the treatment of endometriosis after conservative surgery 1987
- Indikationen zur In-vitro-Fertilisation 1987
- Interim report of a study of danazol for the treatment of endometriosis 1985
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1985
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1984
- Regression of endometriosis following shorter treatment with, or lower dose of danazol: Comparison of pre‐ and post‐treatment laparoscopic findings in the Scandinavian multi‐center study 1984
- Pregnancy rates following various therapy modes for endometriosis in infertile patients 1984
- Endometriosis 1984
- Free testosterone levels during danazol therapy 1983
- Danazol and gestagen displacement of testosterone and influence on sex-hormone-binding globulin capacity 1982
- Endometriosis—continuing conundrum 1980
- Danazol in the Treatment of Endometriosis 1980
- Endometriosis--continuing conundrum. 1980
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