Management of Stage III and IV endometriosis: a 10-year experience

C Napolitano, Carlo Napolitano, Napolitano C, Marziani R, R Marziani, B Mossa, Mossa B, L. Perniola, Perniola L, Giuseppe Benagiano, G Benagiano, Benagiano G
European journal of obstetrics, gynecology, and reproductive biology · 1994 · vol. 53(3) , pp. 199–204 · doi:10.1016/0028-2243(94)90119-8 · PMID:8200467 · W2064670940
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This study reports on the management outcomes of 10 years of experience with stage III and IV endometriosis in patients.

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Abstract

A retrospective analysis is reported of the management of 117 cases of infertility associated with Stage III and IV endometriosis. Combined medico-microsurgical treatment was selected in 75.3% of Stage III cases and in 83.3% of those on Stage IV. Medication consisted of medroxyprogesterone acetate in 26 patients and danazol in the remaining 64. Microsurgery alone was utilized in 24.7% of Stage III patients and in 16.6% of those on Stage IV. Both surgery alone and the combined therapy had a profound positive effect on subjective symptoms: dysmenorrhea, dyspareunia and pelvic pain. Following combined therapy, pregnancy was achieved in 34.4% of all women. Respective figures are 30.7% for medroxyprogesterone acetate (29.4% Stage III and 33.3% Stage IV) and 35.9% for danazol (37.7% Stage III and 27.2% Stage IV). In the group of patients treated by surgery alone, pregnancy occurred in 25.9%. Of the pregnancies in women with Stage III endometriosis, 25 were carried to term and 6 ended with a spontaneous abortion; figures for Stage IV women are 5 and 2, respectively. Second-look laparoscopy was performed in 49 of the 79 patients who failed to conceive, at 12-36 months after treatment; persistent genital pathology, to which infertility could be attributed, was found in 77.5% of them.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Infertility, Female Combined Modality Therapy Danazol Danazol Danazol Endometriosis Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Infertility, Female Laparoscopy Medroxyprogesterone Acetate Medroxyprogesterone Acetate Medroxyprogesterone Acetate Menstruation Disturbances Microsurgery

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (58)

Cited by (5)

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License: CC0 · commercial use OK