Placebo-controlled comparison of danazol and high-dose medroxypro-gesterone acetate in the treatment of endometriosis after conservative surgery

Sakari Telimaa, S Telimaa, Antti Kauppila, L Rönnberg, A Kauppila
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 1987 · vol. 1(4) , pp. 363–371 · doi:10.3109/09513598709082709 · PMID:2972171 · W2038644561
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Postoperative treatment of advanced endometriosis with danazol or high-dose medroxyprogesterone acetate, compared to placebo, significantly reduced pelvic pain and peritoneal lesion size.

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Abstract

To evaluate the clinical value of postoperative hormone therapy in endometriosis, 60 patients with advanced disease were randomized to receive in a double-blind study danazol (200 mg, 3 times daily), medroxyprogesterone acetate (MPA) (100 mg daily) or placebo post-operatively for 6 months. Treatment efficacy was evaluated clinically and at laparoscopy 6 months after medication. In relation to placebo, danazol and high-dose MPA treatments, which did not differ from each other in efficacy, significantly alleviated pelvic pain. In addition, the peritoneal endometriosis lesions found at 6-months laparoscopy were significantly smaller in the MPA and danazol groups than in the placebo group. Breakthrough bleeding, weight gain and acne complicated danazol treatment but only breakthrough bleeding complicated MPA treatment. These data suggest that postoperative treatment of advanced endometriosis with high-dose MPA or danazol is clinically beneficial.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Danazol Endometriosis Medroxyprogesterone Pregnadienes Analysis of Variance Danazol Double-Blind Method Endometriosis Endometriosis Female Humans Medroxyprogesterone Medroxyprogesterone Medroxyprogesterone Acetate Postoperative Care Pregnadienes Random Allocation

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