Progestin-Like Effects of Danazol on Rabbit Uterus*
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Danazol treatment in rabbits increased uteroglobin synthesis and decreased progestin and estrogen receptor concentrations, exhibiting progestin-like activity mediated by binding to the uterine progestin receptor.
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Abstract
The action of danazol on cytosol and nuclear progestin and estrogen receptor concentrations and on the induction of uteroglobin synthesis were studied in the rabbit uterus in vivo. In addition, the relative binding affinity of danazol for the uterine progestin receptor was measured in vitro. Administration of increasing doses of danazol (10, 50, or 100 mg/kg BW daily) for 5 days to adult rabbits tended to decrease the concentrations of cytosol and nuclear progestin and estrogen receptors, whereas the uterine uteroglobin content increased with increasing doses of danazol. Progesterone (1 mg/kg BW daily) caused changes which were greater than those caused by the largest dose of danazol. Danazol was found to bind to the uterine progestin receptor in vitro with an affinity approximately 3.3% of that of progesterone. These findings suggest that danazol has a profound progestin-like activity in the rabbit uterus which may be mediated through binding to cytosol progestin receptors.
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Cited by (13)
- Vaginal patterns during danazol and buserelin acetate therapy for endometriosis: structural and ultrastructural study 1993
- Endometrial patterns during therapy with danazol or gestrinone for endometriosis: Structural and ultrastructural study 1992
- Effects of an androgenic derivative on pre-established mammary tumours chemically induced in the rat 1991
- Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate 1990
- Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis 1987
- Effect of progestins, androgens, estrogens and antiestrogens on3H-thymidine uptake by human endometrial and endosalpinx cells in vitro 1987
- Placebo-controlled comparison of danazol and high-dose medroxypro-gesterone acetate in the treatment of endometriosis after conservative surgery 1987
- Growth inhibition by danazol in a human endometrial cancer cell line with estrogen-independent progesterone receptors 1987
- Direct biphasic effects of danazol on gonadotropin-dependent differentiation of cultured rat granulosa cells 1986
- Danazol binds to progesterone receptors and inhibits the growth of human endometrial cancer cells in vitro 1986
- Steroidal regulation of endometriosis tissue: lack of induction of 17β-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol 1985
- Short‐term effects of danazol and medroxyprogesterone acetate on cytosol and nuclear estrogen and progestin receptors, 17β‐hydroxysteroid dehydrogenase activity, histopathology, and ultrastructure of human endometrial adenocarcinoma 1985
- Cytosol estrogen and progestin receptor concentrations and 17β‐hydroxysteroid dehydrogenase activities in the endometrium and endometriotic tissue 1984
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- last seen: 2026-05-10T10:56:23.340211+00:00
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