Short‐term effects of danazol and medroxyprogesterone acetate on cytosol and nuclear estrogen and progestin receptors, 17β‐hydroxysteroid dehydrogenase activity, histopathology, and ultrastructure of human endometrial adenocarcinoma
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Danazol and medroxyprogesterone acetate treatments increased 17-HSD activity and induced secretory changes in endometrial adenocarcinoma, supporting danazol's progestin-like effects.
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Abstract
We measured concentrations of cytosol and nuclear estrogen, as well as progestin receptors and activities of 17 beta-hydroxysteroid dehydrogenase (17-HSD), and examined histopathology and ultrastructure of endometrial carcinoma specimens taken before and after one-week danazol (200 mg, 3 times daily) or medroxyprogesterone acetate (MPA, 100 mg daily) treatments in 14 and 16 patients, respectively. A typical progestin effect, a significant increase in the activity of 17-HSD, was observed after both treatments. The post-therapy 17-HSD activities correlated significantly with the pretreatment cytosol progestin receptor concentrations in both treatment groups. Both MPA and danazol decreased the proliferative activity and increased the secretory activity of the malignant epithelial endometrial cells. These biochemical and morphological results support the concept that danazol has progestin-like actions on the human endometrium, and might therefore be an alternative for hormonal treatment of endometrial carcinoma.
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References (18)
- Danazol has progestin-like actions on the human endometrium via openalex
- Danazol treatment of advanced breast cancer. via openalex
- Progestin-Like Effects of Danazol on Rabbit Uterus* via openalex
- Treatment of breast cancer with danazol. via openalex
- doi:10.1016/0002-9378(72)90769-7 via openalex
- doi:10.1007/978-3-642-67568-3_14 via openalex
- doi:10.1016/s0021-9258(19)43455-8 via openalex
- doi:10.1002/ijc.2910240505 via openalex
- doi:10.1016/s0002-9378(15)33275-0 via openalex
- doi:10.3109/00016347109157278 via openalex
- doi:10.1530/acta.0.0780574 via openalex
- doi:10.1016/0090-8258(82)90094-4 via openalex
- W6643992471 via openalex
- doi:10.1016/0002-9378(81)90611-6 via openalex
- doi:10.1111/j.1749-6632.1977.tb29416.x via openalex
- doi:10.1016/0002-9378(82)90077-1 via openalex
- doi:10.1002/1097-0142(19810715)48:1+<638::aid-cncr2820481331>3.0.co;2-1 via openalex
- doi:10.1002/1097-0142(19821115)50:10<2157::aid-cncr2820501031>3.0.co;2-7 via openalex
Cited by (11)
- Androgens, oestrogens and endometrium: a fine balance between perfection and pathology 2020
- Changing concepts of medical treatment of endometriosis 1993
- Endometrial patterns during therapy with danazol or gestrinone for endometriosis: Structural and ultrastructural study 1992
- Placebo-controlled comparison of hormonal and biochemical effects of danazol and high-dose medroxyprogesterone acetate 1990
- Elevated serum levels of endometrial secretory protein PP14 in patients with advanced endometriosis 1989
- STEROIDAL DRUGS IN ENDOMETRIOSIS 1989
- Inhibitory effects of danazol and medroxyprogesterone acetate on [3H]thymidine incorporation in human endometrial cancer cells 1988
- Preliminary report on the use of danazol in the treatment of endometrial adenomatous hyperplasia 1988
- Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis 1987
- Placebo-controlled comparison of danazol and high-dose medroxypro-gesterone acetate in the treatment of endometriosis after conservative surgery 1987
- Cytosol estrogen and progestin receptor concentrations and 17β‐hydroxysteroid dehydrogenase activities in the endometrium and endometriotic tissue 1984
SciLite annotations
chemicals 12
danazol
medroxyprogesterone
acetate
estrogen
estrogen
danazol
medroxyprogesterone
acetate
progestin
danazol
danazol
progestin
organisms 2
human
human
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