Growth inhibition by danazol in a human endometrial cancer cell line with estrogen-independent progesterone receptors

Naoki Terakawa, Hiromasa Ikegami, Ikuya Shimizu, Toshihiro Aono, Osamu Tanizawa, Keishi Matsumoto
In: Journal of Steroid Biochemistry · 1987 · vol. 28(5) , pp. 571–574 · doi:10.1016/0022-4731(87)90517-6 · PMID:3682823 · W2147418077
article OA: closed CC0 ⤵ 6 in-corpus citations
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Danazol inhibited the growth of a human endometrial cancer cell line that expressed estrogen-independent progesterone receptors.

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Abstract

Since we recently found that danazol, an isoxazol derivative of ethinyltestosterone, has a growth-inhibitory effect on human endometrial cancer cells in primary culture, the effects of danazol on a human endometrial cancer cell line (IK-90 cells), which contains estrogen-independent progesterone receptors (PR), were investigated in the present study. The addition of danazol (1 nM-1 microM) in culture medium caused a decrease in the growth of IK-90 cells in a dose-dependent manner. Competitive binding studies showed that danazol effectively binds to PR in IK-90 cells, and the binding affinity for PR was estimated to be 6.0% of that of R5020. The addition of 1 microM danazol in culture medium resulted in a rapid and significant increase in nuclear PR with a concomitant decrease in cytoplasmic PR in the cells. These findings suggest that danazol has a growth-inhibitory effect on human endometrial adenocarcinoma cells directly through PR system in the cells.

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