Danazol binding to steroid receptors in human uterine endometrium

Teruhiko Tamaya, T Tamaya, Tamaya T, KEISUKE WADA, K Wada, Wada K, J Fujimoto, Jiro Fujimoto, Fujimoto J, Yamada T, Toshio Yamada, T Yamada, Hiroji Okada, H Okada, Okada H
Fertility and sterility · 1984 · vol. 41(5) , pp. 732–735 · doi:10.1016/s0015-0282(16)47840-4 · PMID:6714450 · W110242816
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This study investigated the binding affinity of danazol to estrogen and progesterone receptors within human uterine endometrial tissue.

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Abstract

To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Danazol bound to endometrial receptors for estrogen, progesterone, and androgen and seemed to bind to endometrial intracellular corticosteroid-binding globulin and sex-hormone-binding globulin. Danazol occupies almost all binding sites of steroids in the steroid target cells in spite of the presence of endogenous steroids. It is speculated that the binding behavior of danazol may be related to its therapeutic effect on endometriosis.

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MeSH descriptors

Danazol Endometrium Pregnadienes Receptors, Androgen Receptors, Estrogen Receptors, Progesterone Receptors, Steroid Binding Sites Danazol Danazol Dose-Response Relationship, Drug Endometrium Female Humans In Vitro Techniques Pregnadienes Receptors, Androgen Receptors, Estrogen Receptors, Progesterone Receptors, Steroid

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References (19)

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