Danazol decreases transcription of estrogen receptor gene in human monocytes

Jiro Fujimoto; Masashi Hori; Toshiya Itoh; Satoshi Ichigo; Miki Nishigaki; Teruhiko Tamaya

doi:10.1016/0306-3623(94)00227-e

Danazol decreases transcription of estrogen receptor gene in human monocytes

Jiro Fujimoto, Masashi Hori, Toshiya Itoh, Satoshi Ichigo, Miki Nishigaki, Teruhiko Tamaya

In: General Pharmacology: The Vascular System · 1995 · vol. 26(3) , pp. 507–516 · doi:10.1016/0306-3623(94)00227-e · PMID:7540578 · W2059967126

article OA: closed CC0 ⤵ 1 in-corpus citation

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This study investigated and found that danazol effectively reduces the transcription of the estrogen receptor gene within human monocytes.

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Abstract

1. Administration of danazol for over one month reduced the levels of estrogen receptor (ER) and its mRNA to approximately 50 and 20%, respectively in monocytes. 2. Danazol did not alter the degradation rate of ER mRNA in monocytes. 3. Danazol decreased the transcription rate of ER gene to approximately 50% in monocytes in a run-on assay. 4. Danazol may release estrogen predominance via the reduction of transcription for ER gene, which leads to the reduction of ER mRNA and ER expressions in monocytes.

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Cited by (1)

Expression und Regulation von Enzymen des Östrogenmetabolismus in humanen Endometriumläsionen kultiviert in der Nacktmaus 2007

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[1] Danazol binding to steroid receptors in human uterine endometrium via openalex

[2] Danazol Suppresses the Production of Interleukin‐1β and Tumor Necrosis Factor by Human Monocytes via openalex

[3] Different Effects on Oestrogen Binding Sites and Anti-Oestrogenic Action of Danazol and Progesterone via openalex

[4] Estrogen binding sites in peripheral blood monocytes and effects of danazol on their sites in vitro via openalex

[5] Interleukin-1: a possible role in the infertility associated with endometriosis via openalex

[6] Interleukin‐1: A possible role in the infertility associated with endometriosis via openalex

[7] doi:10.1093/oxfordjournals.jbchem.a128668 via openalex

[8] doi:10.1007/978-1-4757-6589-2 via openalex

[9] doi:10.1016/0020-7292(89)90287-7 via openalex

[10] doi:10.1016/0002-9378(89)90179-8 via openalex

[11] doi:10.1016/s0015-0282(16)59945-2 via openalex

[12] doi:10.1006/abio.1987.9999 via openalex

[13] doi:10.1016/s0015-0282(16)43869-0 via openalex

[14] doi:10.1016/0003-2697(87)90021-2 via openalex

[15] doi:10.4049/jimmunol.139.7.2250 via openalex

[16] doi:10.1016/s0015-0282(16)60185-1 via openalex

[17] doi:10.1042/bj0620315 via openalex

[18] doi:10.1016/0003-2697(76)90527-3 via openalex

[19] W579464960 via openalex

[20] doi:10.1210/mend-5-10-1527 via openalex

[21] doi:10.1111/j.1749-6632.1949.tb27297.x via openalex

[22] doi:10.1006/abio.1976.9999 via openalex

[23] doi:10.1210/endo-129-6-3430 via openalex