Different Effects on Oestrogen Binding Sites and Anti-Oestrogenic Action of Danazol and Progesterone
article
OA: closed
CC0
⤵ 3 in-corpus citations
AI-generated summary
Progesterone and danazol inhibited estrogen-stimulated uterine weight increases by decreasing estrogen binding sites, with danazol potentially acting via a different pathway than progesterone.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Rabbit uterus contains type I and II oestrogen binding sites in the cytosol, and nuclear fractions. Oestrogen-stimulated increase in uterine weight was inhibited by concurrent treatment with progesterone or danazol. Oestrogen-induced type I binding sites were decreased by progesterone and to a lesser extent by danazol, while oestrogen-induced type II sites were decreased almost equally in the two groups. Neither progesterone nor danazol alone caused any detectable changes in uterine weight. These findings may suggest that the anti-oestrogenic effect on uterine weight is more correlated with the change in type II binding sites of oestrogen than that in type I sites. Thus, danazol may exert anti-oestrogenic actions through a pathway independent from that of progesterone.
My notes (saved in your browser only)
Citation neighborhood (sparse)
Too few in-corpus citations on either side for a chart; here are the lists.
Cites (2)
- Danazol binding to steroid receptors in human uterine endometrium 1984
- COMPARISON OF CELLULAR LEVELS OF STEROID RECEPTORS IN UTERINE LEIOMYOMA AND MYOMETRIUM 1985
Cited by (3)
- Danazol decreases transcription of estrogen receptor gene in human monocytes 1995
- Estrogen binding sites in peripheral blood monocytes and effects of danazol on their sites in vitro 1992
- Effects of danazol and medroxyprogesterone acetate on estrogen-(estradiol and estriol) specific binding sites in rabbit uterus 1995
References (7)
- COMPARISON OF CELLULAR LEVELS OF STEROID RECEPTORS IN UTERINE LEIOMYOMA AND MYOMETRIUM via openalex
- Danazol binding to steroid receptors in human uterine endometrium via openalex
- doi:10.1007/978-3-642-81339-9 via openalex
- doi:10.1042/bj0620315 via openalex
- doi:10.1016/0022-4731(79)90513-2 via openalex
- doi:10.1016/s0015-0282(16)43869-0 via openalex
- doi:10.1016/0022-4731(81)90257-0 via openalex
Cited by (3)
- Danazol decreases transcription of estrogen receptor gene in human monocytes 1995
- Effects of danazol and medroxyprogesterone acetate on estrogen-(estradiol and estriol) specific binding sites in rabbit uterus 1995
- Estrogen binding sites in peripheral blood monocytes and effects of danazol on their sites in vitro 1992
Source provenance
- openalex
- last seen: 2026-05-10T10:29:31.028256+00:00
License: CC0
· commercial use OK