Estrogen binding sites in peripheral blood monocytes and effects of danazol on their sites in vitro

KEISUKE WADA; Toshiya Itoh; M Nakagawa; Ryou Misao; Hidehiro Mori; Teruhiko Tamaya

doi:10.1016/0306-3623(92)90150-i

Estrogen binding sites in peripheral blood monocytes and effects of danazol on their sites in vitro

KEISUKE WADA, Toshiya Itoh, M Nakagawa, Ryou Misao, Hidehiro Mori, Teruhiko Tamaya

In: General Pharmacology: The Vascular System · 1992 · vol. 23(4) , pp. 693–700 · doi:10.1016/0306-3623(92)90150-i · PMID:1397976 · W2062932874

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This study investigated estrogen binding sites in peripheral blood monocytes and the in vitro effects of danazol on these sites.

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Abstract

1. This study was designed to investigate the presence of estrogen type I (high affinity, low capacity) and type II (low affinity, high capacity) binding sites in human peripheral blood monocytes and the effects of danazol on these sites. 2. These two types of estrogen binding sites existed in human peripheral blood monocytes. 3. Danazol bound to these sites in high concentration (10(-6) M, clinical serum concentration during danazol therapy) and decreased the number of both sites. 4. It is suggested that danazol has an anti-estrogenic action to the monocytes through the competition and suppression of estrogen binding sites as seen in the estrogen target organ.

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Cites (4)

Cited by (1)

Danazol decreases transcription of estrogen receptor gene in human monocytes 1995

References (21)

Different Effects on Oestrogen Binding Sites and Anti-Oestrogenic Action of Danazol and Progesterone via openalex
Interleukin-1: a possible role in the infertility associated with endometriosis via openalex
Interleukin‐1: A possible role in the infertility associated with endometriosis via openalex
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Cited by (1)

Danazol decreases transcription of estrogen receptor gene in human monocytes 1995

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[1] Interleukin‐1: A possible role in the infertility associated with endometriosis 1988

[2] Interleukin-1: a possible role in the infertility associated with endometriosis 1987

[3] Different Effects on Oestrogen Binding Sites and Anti-Oestrogenic Action of Danazol and Progesterone 1991

[4] Studies on type II estrogen binding sites : Relation between the effects on these sites of estrogen priming and the antiestrogen effects by danazol and progesterone. 1986