Danazol decreases transcription of estrogen receptor gene in human monocytes

J Fujimoto; Jiro Fujimoto; Masashi Hori; M Hori; Toshiya Itoh; T Itoh; Satoshi Ichigo; S Ichigo; M Nishigaki; Miki Nishigaki; Teruhiko Tamaya; T Tamaya

doi:10.1016/0306-3623(94)00227-e

Danazol decreases transcription of estrogen receptor gene in human monocytes

J Fujimoto, Jiro Fujimoto, Masashi Hori, M Hori, Toshiya Itoh, T Itoh, Satoshi Ichigo, S Ichigo, M Nishigaki, Miki Nishigaki, Teruhiko Tamaya, T Tamaya

General pharmacology · 1995 · vol. 26(3) , pp. 507–516 · doi:10.1016/0306-3623(94)00227-e · PMID:7540578 · W2059967126

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This study investigated and found that danazol effectively reduces the transcription of the estrogen receptor gene within human monocytes.

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Abstract

1. Administration of danazol for over one month reduced the levels of estrogen receptor (ER) and its mRNA to approximately 50 and 20%, respectively in monocytes. 2. Danazol did not alter the degradation rate of ER mRNA in monocytes. 3. Danazol decreased the transcription rate of ER gene to approximately 50% in monocytes in a run-on assay. 4. Danazol may release estrogen predominance via the reduction of transcription for ER gene, which leads to the reduction of ER mRNA and ER expressions in monocytes.

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MeSH descriptors

Danazol Gene Expression Regulation Monocytes Receptors, Estrogen Adult Base Sequence Binding, Competitive Binding, Competitive Blotting, Southern Danazol Female Gene Expression Regulation Humans In Vitro Techniques Kinetics Molecular Sequence Data Monocytes Monocytes Polymerase Chain Reaction Receptors, Estrogen

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Cited by (1)

Expression und Regulation von Enzymen des Östrogenmetabolismus in humanen Endometriumläsionen kultiviert in der Nacktmaus 2007

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[1] Danazol binding to steroid receptors in human uterine endometrium via openalex

[2] Danazol suppresses the production of interleukin-1 beta and tumor necrosis factor by human monocytes via openalex

[3] Different effects on oestrogen binding sites and anti-oestrogenic action of danazol and progesterone via openalex

[4] Estrogen binding sites in peripheral blood monocytes and effects of danazol on their sites in vitro via openalex

[5] Interleukin-1: a possible role in the infertility associated with endometriosis via openalex

[6] Interleukin-1: a possible role in the infertility associated with endometriosis via openalex

[7] doi:10.1093/oxfordjournals.jbchem.a128668 via openalex

[8] doi:10.1007/978-1-4757-6589-2 via openalex

[9] doi:10.1016/0020-7292(89)90287-7 via openalex

[10] doi:10.1016/0002-9378(89)90179-8 via openalex

[11] doi:10.1016/s0015-0282(16)59945-2 via openalex

[12] doi:10.1006/abio.1987.9999 via openalex

[13] doi:10.1016/s0015-0282(16)43869-0 via openalex

[14] doi:10.1016/0003-2697(87)90021-2 via openalex

[15] doi:10.4049/jimmunol.139.7.2250 via openalex

[16] doi:10.1016/s0015-0282(16)60185-1 via openalex

[17] doi:10.1042/bj0620315 via openalex

[18] doi:10.1016/0003-2697(76)90527-3 via openalex

[19] W579464960 via openalex

[20] doi:10.1210/mend-5-10-1527 via openalex

[21] doi:10.1111/j.1749-6632.1949.tb27297.x via openalex

[22] doi:10.1006/abio.1976.9999 via openalex

[23] doi:10.1210/endo-129-6-3430 via openalex