Glucose tolerance and insulin resistance after danazol treatment

Catherine A. Vaughan-williams, S Shalet, Ian Laing
In: Journal of Obstetrics and Gynaecology · 1989 · vol. 9(3) , pp. 229–232 · doi:10.3109/01443618909151048 · W1997777644
Non-randomised trial OA: closed CC0 ⤵ 1 in-corpus citation
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Danazol treatment in non-diabetic women with endometriosis resulted in impaired glucose tolerance and increased insulin response, likely due to its androgenic effects.

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Abstract

SummarySummaryBlood glucose and serum insulin concentrations were measured during an oral glucose tolerance test in nine non-diabetic women before and 6 weeks alter starting treatment with danazol for pelvic endometriosis.Danazol induced a mild deterioration in glucose tolerance and a marked increase in the insulin response to glucose loading. Sex hormone binding globulin concentrations were reduced by 80 per cent but there was no change in total testosterone and oestradiol concentrations.These data confirm that danazol increases insulin resistance in non-diabetic women, probably as a result of its androgenic properties. Danazol treatment should probably be avoided in women with impaired glucose tolerance.

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endometriosis

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