Treatment with danazol and plasma glucagon concentration

G Williams, Williams G, Gareth Williams, F. Lofts, Lofts F, HS Fuessl, Fuessl H, H Fuessl, S Bloom, Stephen R. Bloom
British medical journal (Clinical research ed.) · 1985 · vol. 291(6503) , pp. 1155–1156 · doi:10.1136/bmj.291.6503.1155 · PMID:3931833 · PMC1417875 · W1969498424
Observational OA: bronze CC0 ⤵ 5 in-corpus citations
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This study found that danazol treatment is associated with severe hyperglucagonaemia, with some patients showing levels suggestive of glucagonoma, necessitating awareness to avoid unnecessary investigations.

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Abstract

The association between treatment with danazol and hyperglucagonaemia was studied. Plasma glucagon concentrations were measured during an oral glucose tolerance test in seven women taking danazol and six healthy controls not taking danazol. Results showed that treatment with danazol is associated with severe hyperglucagonaemia, and in three patients glucagon concentrations reached the range suggestive of glucagonoma. It is important to recognise that this increasingly used drug may cause severe hyperglucagonaemia to prevent patients treated with danazol undergoing unnecessary investigations to localise glucagonoma.

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MeSH descriptors

Danazol Glucagon Lupus Erythematosus, Systemic Pregnadienes Adult Danazol Female Glucagon Glucose Tolerance Test Humans Insulin Insulin Lupus Erythematosus, Systemic Lupus Erythematosus, Systemic Pregnadienes

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