Adrenal Function During Chronic Danazol Administration

Anne Colston Wentz, Georgeanna Seegar Jones, Mason C. Andrews, Theodore M. King
In: Fertility and Sterility · 1975 · vol. 26(11) , pp. 1113–1115 · doi:10.1016/s0015-0282(16)41479-2 · PMID:171176 · W2417686084
article OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper investigated adrenal function in individuals undergoing chronic treatment with danazol, a synthetic androgen.

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Abstract

Ten healthy female volunteers received Danazol, 400 mg twice daily for 90 days. Adrenal function testing then showed a normal capacity of the gland to respond to stimulation with synthetic adrenocorticotrophic hormone, and a lack of suppression of central areas controlling adrenal function by a normal response to the metyrapone challenge.

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