Hormonal changes associated with Danazol therapy.
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Danazol therapy for endometriosis reduced plasma estradiol and progesterone to follicular phase levels while maintaining low normal FSH and unchanged LH, with hormone parameters returning to normal post-treatment.
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Abstract
During a 6-month course of treatment of endometriosis with Danazol, a synthetic derivative of 17alpha-ethinyl testosterone, the following hormonal changes were found. Plasma LH remained essentially unchanged but FSH concentration was consistently in the low normal range. Plasma estradiol, especially after the fourth week of therapy, dropped to levels that did not exceed 30 pg/ml throughout the 6-month period of therapy. Plasma progesterone concentration was consistent with follicular phase levels. In the months after discontinuation of Danazol, all hormone parameters were strongly suggestive of normal ovulatory cycles. Danazol did not displace estradiol bound by endometrial cytosol.
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Cited by (47)
- Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure 2020
- Danazol regulates the functions of normal human endometrial stromal cell subpopulations by modifying endometrial cytokine networks 2009
- Altered uterine artery blood flow impedance after danazol therapy: possible mode of action in dysfunctional uterine bleeding 1999
- Danazol enhances Fas-mediated apoptosis in human endometrial epithelial cells within normal physiology 1998
- Danazol concentrations in ovary, uterus, and serum and their effect on the hypothalamic-pituitary-ovarian axis during vaginal administration of a danazol suppository 1995
- Leukocyte Subpopulation Changes in Rats With Autotransplanted Endometrium and the Effect of Danazol 1995
- Tissue Factors Influencing Growth and Maintenance of Endometriosis<sup>a</sup> 1991
- Thermoregulatory and endocrine effects of a low dose of danazol in postmenopausal women: Interaction with the effect of naloxone 1991
- Cytoplasmic and nuclear estrogen binding capacity in the rat uterus during treatment with danazol and testosterone 1986
- Effects of danazol on steroidogenesis and gonadotropic responsiveness in isolated human preovulatory follicular cells 1986
- Inhibitory effects of danazol on steroidogenesis in cultured human granulosa cells 1986
- Danazol inhibits steroidogenesis by the human ovary in vivo 1986
- Gynecologic Problems of Adolescence 1985
- TREATMENT WITH DANAZOL OF URETERAL OBSTRUCTION CAUSED BY ENDOMETRIOSIS 1985
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1985
- Management of pelvic endometriosis with low-dose danazol 1985
- Hot flashes in postmenopausal women ameliorated by danazol 1985
- The influence of danazol on pituitary function and on the ovarian follicular hormone secretion in premenopausal women 1984
- Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone 1984
- Endocrine effects of danazol in the treatment of endometriosis 1984
- Effect of danazol on serum concentrations of pituitary gonadotropins in postmenopausal women 1984
- Effects of danazol on pulsatile gonadotropin patterns and on serum estradiol levels in normally cycling women 1983
- Influence of danazol on cytoplasmic and nuclear estrogen binding capacity in the uterus 1983
- THE INTERACTION OF HUMAN ENDOMETRIAL AND MYOMETRIAL STEROID RECEPTORS WITH DANAZOL 1983
- Influence of danazol treatment during the luteal phase on pituitary and ovarian function during the subsequent menstrual cycle 1982
- Effects of danazol on gonadal steroidogenesis in patients with a complete form of testicular feminization 1982
- Hormonal and Surgical Management of Pelvic Endometriosis 1982
- In Vitro Effect of Danazol on Luteinizing Hormone-Releasing Hormone-Stimulated Luteinizing Hormone Release in Rat Anterior Pituitary Cell Cultures in Vitro * 1981
- The Use of Danazol for Ureteral Obstruction Caused by Endometriosis 1981
- Management of Pelvic Endometriosis with Low-Dose Danazol 1981
- Danazol: Endocrine consequences in healthy women 1981
- Danazol suppression of luteinizing hormone secretion: a role for danazol-androgen receptor interaction within the brain-pituitary complex 1981
- Treatment of pulmonary endometriosis with danazol 1981
- Danazol in the Treatment of Endometriosis 1980
- Pharmacology and Pharmacokinetics of Danazol 1980
- Danazol inhibits human adrenal 21-and 11β-hydroxylation invitro 1980
- Mechanism of induction of luteal phase defects by danazol 1980
- EFFECT OF DANAZOL ON SERUM GONADOTROPHINS AND STEROID HORMONE CONCENTRATIONS IN WOMEN WITH MENORRHAGIA 1980
- Competitive inhibition by Danazol of oestradiol binding to rabbit and ovine uterine oestradiol receptor 1980
- Danazol Binding to Rat Androgen, Glucocorticoid, Progesterone, and Estrogen Receptors: Correlation With Biologic Activity 1979
- Effect of danazol on estradiol-17β and progesterone secretion by porcine ovarian cells in vitro 1979
- Danazol—A Steroid with a Unique Combination of Actions 1979
- THE EFFECT OF DANAZOL ON MENORRHAGIA, COAGULATION MECHANISMS, HAEMATOLOGICAL INDICES AND BODY WEIGHT 1979
- Danazol therapy in hormone-sensitive mammary carcinoma 1977
- Danazol Inhibits Steroidogenesis in the Rat Testis<i>in Vitro</i> 1977
- Danazol Inhibits Steroidogenesis 1977
- Progestational activity of Danazol in the human female subject 1976
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