Danazol concentrations in ovary, uterus, and serum and their effect on the hypothalamic-pituitary-ovarian axis during vaginal administration of a danazol suppository

Takahiro Mizutani, Shigeru Nishiyama, Ichiro Amakawa, Akitoshi Watanabe, Karo Nakamuro, Nobuyuki Terada
In: Fertility and Sterility · 1995 · vol. 63(6) , pp. 1184–1189 · doi:10.1016/s0015-0282(16)57594-3 · PMID:7750586 · W2363284090
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This study measured danazol concentrations in ovarian, uterine, and serum tissues following vaginal suppository administration and analyzed its impact on the hypothalamic-pituitary-ovarian axis.

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Abstract

ObjectiveTo determine danazol concentrations in the ovary, uterus, and serum during daily vaginal administration of a danazol suppository and to examine its effect on the hypothalamic-pituitary-ovarian axis.DesignSampling of tissues after vaginal or oral administration of danazol and sampling of blood during control and danazol-administration menstrual cycles.SettingOutpatient volunteers and inpatients at a public hospital.ParticipantsThirty patients who were to undergo hysterectomy and oophorectomy because of uterine leiomyoma and eight regularly menstruating volunteers.InterventionsDanazol was administered as a vaginal suppository (100 mg) or orally (400 mg).Main outcome measureDanazol concentrations in the ovary, uterus, and serum, and serum E2 and P levels.ResultsDanazol concentrations in the ovary and uterus after daily vaginal administration of a suppository containing 100 mg danazol were comparable to those after daily oral administration of 400 mg danazol, but the serum danazol concentration was much lower. Menstrual cycle patterns of serum E2 and P levels were normal during daily vaginal administration of a danazol suppository.ConclusionDaily administration of a suppository containing 100 mg danazol produces high ovarian and uterine concentrations but low serum concentrations, and no effect was detected on the hypothalamic-pituitary-ovarian axis.

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