Vaginal danazol for women with rectovaginal endometriosis and pain symptoms persisting after insertion of a levonorgestrel‐releasing intrauterine device

Simone Ferrero, Daniela Tramalloni, Pier Luigi Venturini, Valentino Remorgida
International Journal of Gynecology & Obstetrics · 2011 · vol. 113(2) , pp. 116–119 · doi:10.1016/j.ijgo.2010.11.015 · PMID:21333989 · W2009231867
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This pilot study found that vaginal danazol treatment decreased pain symptoms and rectovaginal nodule volume in women with rectovaginal endometriosis despite prior LNG-IUD use.

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Abstract

OBJECTIVE: To evaluate the effectiveness of treatment with vaginal danazol in improving the pain symptoms caused by rectovaginal endometriosis that persist after insertion of a levonorgestrel-releasing intrauterine device (LNG-IUD). METHODS: This pilot observational study included 15 women with rectovaginal endometriosis and pain symptoms persisting after LNG-IUD insertion. Vaginal danazol (100mg per day) was self-administered for 6months. The intensity of pain symptoms and the volume of rectovaginal endometriotic nodules were evaluated. RESULTS: Twelve women were satisfied or very satisfied with the treatment. After treatment with vaginal danazol for 3months, there was a significant decrease in the intensity of pain symptoms compared with their intensity before the administration of danazol. The intensity of pain symptoms decreased further at 6-month follow-up. The volume of the rectovaginal nodules decreased after treatment with vaginal danazol for 6months (1.7±0.8cm(3)) compared with the baseline volume (2.3±0.9cm(3); P<0.001). Adverse effects of the treatment were minimal and well tolerated. CONCLUSION: Although a placebo effect cannot be excluded, the results indicate that vaginal danazol decreases the severity of endometriosis-related pain symptoms after LNG-IUD insertion.

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Condition tags

mesh:D004715endometriosisbowel_endometriosis

MeSH descriptors

Danazol Endometriosis Estrogen Antagonists Levonorgestrel Administration, Intravaginal Adult Contraceptive Agents, Female Contraceptive Agents, Female Contraceptive Agents, Female Danazol Danazol Danazol Endometriosis Endometriosis Estrogen Antagonists Estrogen Antagonists Estrogen Antagonists Female Follow-Up Studies Humans

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References (23)

Cited by (25)

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