Vaginally Administered Danazol: An Overlooked Option in the Treatment of Rectovaginal Endometriosis?

Godin R; Richard Godin; Marcoux V; Violaine Marcoux

doi:10.1016/s1701-2163(16)30075-5

Vaginally Administered Danazol: An Overlooked Option in the Treatment of Rectovaginal Endometriosis?

Godin R, Richard Godin, Marcoux V, Violaine Marcoux

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC · 2015 · vol. 37(12) , pp. 1098–1103 · doi:10.1016/s1701-2163(16)30075-5 · PMID:26637082 · W2288794406

review OA: closed CC0 ⤵ 24 in-corpus citations

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This paper reviews the use of vaginally administered danazol as a potential treatment for rectovaginal endometriosis.

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Abstract

Danazol has been used in the treatment of endometriosis and heavy menstrual bleeding for more than 40 years. This medication has both central antigonadotropic actions and direct atrophic effects on endometriotic tissue. Although it demonstrates a high-efficacy profile, the associated side effects have resulted in limited usage. Vaginal administration of the drug may prove favourable specifically in rectovaginal endometriosis. This targeted mode of delivery is associated with a significant reduction in both pain symptoms and nodule size. The relative persistence of these therapeutic benefits is likely related to the direct tissue effects after absorption through the vaginal mucosa. Vaginal administration would also limit systemic propagation of danazol and thus should minimize androgenic side effects. Use of vaginal danazol also improves heavy menstrual bleeding and may even restore fertility in some patients. In this review we provide a critical analysis of the existing literature on the use of vaginal danazol.

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Condition tags

endometriosisbowel_endometriosis

MeSH descriptors

Danazol Danazol Endometriosis Estrogen Antagonists Estrogen Antagonists Administration, Intravaginal Danazol Endometriosis Estrogen Antagonists Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

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A danazol-loaded intrauterine device decreases dysmenorrhea, pelvic pain, and dyspareunia associated with endometriosis via openalex
A New Therapy for Pelvic Endometriosis and Uterine Adenomyosis: Local Effect of Vaginal and Intrauterine Danazol Application via openalex
Clinical outcome of vaginal danazol suppository use in women with pelvic endometriosis via openalex
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Danazol concentrations in ovary, uterus, and serum and their effect on the hypothalamic-pituitary-ovarian axis during vaginal administration of a danazol suppository via openalex
Danazol for pelvic pain associated with endometriosis via openalex
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W6824378097 via openalex
W188346150 via openalex
W1618997004 via openalex
W2046798693 via openalex
W2067202752 via openalex
W2110225766 via openalex
W2133456153 via openalex
W68155038 via openalex

Cited by (25)

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License: CC0 · commercial use OK

[1] Abnormal Uterine Bleeding: Medical Treatment with Vaginal Danazol and Five-Year Follow-up via openalex

[2] A danazol-loaded intrauterine device decreases dysmenorrhea, pelvic pain, and dyspareunia associated with endometriosis via openalex

[3] A New Therapy for Pelvic Endometriosis and Uterine Adenomyosis: Local Effect of Vaginal and Intrauterine Danazol Application via openalex

[4] Clinical outcome of vaginal danazol suppository use in women with pelvic endometriosis via openalex

[5] Clinical Studies with an Antigonadotropin-Danazol via openalex

[6] Combined use of a long-acting gonadotropin-releasing hormone agonist and low-dose danazol in advanced stage endometriosis via openalex

[7] Danazol and urogenital sinus formation in pregnancy via openalex

[8] Danazol concentrations in ovary, uterus, and serum and their effect on the hypothalamic-pituitary-ovarian axis during vaginal administration of a danazol suppository via openalex

[9] Danazol for pelvic pain associated with endometriosis via openalex

[10] Diagnosis, management, and long-term outcomes of rectovaginal endometriosis via openalex

[11] Dienogest in the treatment of endometriosis via openalex

[12] Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age via openalex

[13] Efficacy of vaginal danazol treatment in women with recurrent deeply infiltrating endometriosis via openalex

[14] Gonadotrophin-releasing hormone analogues for pain associated with endometriosis via openalex

[15] Gonadotrophin-releasing hormone analogues for pain associated with endometriosis via openalex

[16] Maintenance therapy involving a tapering dose of danazol or mid/low doses of oral contraceptive after gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain via openalex

[17] Novel conservative medical therapy for uterine adenomyosis with a danazol-loaded intrauterine device via openalex

[18] Novel vaginal danazol ring therapy for pelvic endometriosis, in particular deeply infiltrating endometriosis via openalex

[19] Prevalence and incidence of diagnosed endometriosis and risk of endometriosis in patients with endometriosis-related symptoms: findings from a statutory health insurance-based cohort in Germany via openalex

[20] Serum estradiol and danazol. I. Endometriosis response, side effects, administration interval, concurrent spironolactone and dexamethasone via openalex

[21] The effect of oral contraceptives on aromatase expression in the eutopic endometrium of patients with endometriosis via openalex

[22] The effects of fetal exposure to danazol via openalex

[23] Use of mixed-treatment-comparison methods in estimating efficacy of treatments for heavy menstrual bleeding via openalex

[24] Vaginal danazol for the treatment of endometriosis-related pelvic pain via openalex

[25] Vaginal danazol for women with rectovaginal endometriosis and pain symptoms persisting after insertion of a levonorgestrel‐releasing intrauterine device via openalex

[26] W6824378097 via openalex

[27] W188346150 via openalex

[28] W1618997004 via openalex

[29] W2046798693 via openalex

[30] W2067202752 via openalex

[31] W2110225766 via openalex

[32] W2133456153 via openalex

[33] W68155038 via openalex