A danazol-loaded intrauterine device decreases dysmenorrhea, pelvic pain, and dyspareunia associated with endometriosis

Luigi Cobellis, Cobellis L, Razzi S, Sandro Razzi, Antonio Fava, Fava A, Filiberto M Severi, Filiberto Maria Severi, Igarashi M, Masao Igarashi, Felice Petraglia
Fertility and sterility · 2004 · vol. 82(1) , pp. 239–240 · doi:10.1016/j.fertnstert.2003.11.058 · PMID:15237024 · W2007073683
Non-randomised trial OA: closed CC0 ⤵ 53 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

A danazol-loaded intrauterine device effectively reduced dysmenorrhea, pelvic pain, and dyspareunia in patients diagnosed with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

A danazol-loaded intrauterine device (IUD) containing 300-400 mg of danazol was inserted for 6 months in a group of women (n = 18) (median age 36.6 years; age range: 30 to 46 years) with a histologic diagnosis of endometriosis, referred for recurrent pelvic pain. Dysmenorrhea, dyspareunia, and pelvic pain significantly decreased after the first month, with a persistent effect during the 6 months of IUD insertion. These results show that a danazol-loaded IUD is an effective conservative therapy for patients with endometriosis-related pelvic pain.

My notes (saved in your browser only)

Condition tags

dysmenorrheadyspareuniaendometriosis

MeSH descriptors

Danazol Dysmenorrhea Dyspareunia Endometriosis Estrogen Antagonists Intrauterine Devices, Medicated Intrauterine Devices, Medicated Adult Adult Danazol Danazol Dysmenorrhea Dysmenorrhea Dysmenorrhea Dyspareunia Dyspareunia Dyspareunia Endometriosis Endometriosis Estrogen Antagonists

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (8)

Cited by (50)

Source provenance

europepmc
last seen: 2026-10-08T06:18:23.926119+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:02:35.474120+00:00
License: CC0 · commercial use OK