A danazol-loaded intrauterine device decreases dysmenorrhea, pelvic pain, and dyspareunia associated with endometriosis
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A danazol-loaded intrauterine device effectively reduced dysmenorrhea, pelvic pain, and dyspareunia in patients diagnosed with endometriosis.
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Abstract
A danazol-loaded intrauterine device (IUD) containing 300-400 mg of danazol was inserted for 6 months in a group of women (n = 18) (median age 36.6 years; age range: 30 to 46 years) with a histologic diagnosis of endometriosis, referred for recurrent pelvic pain. Dysmenorrhea, dyspareunia, and pelvic pain significantly decreased after the first month, with a persistent effect during the 6 months of IUD insertion. These results show that a danazol-loaded IUD is an effective conservative therapy for patients with endometriosis-related pelvic pain.
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- Novel vaginal danazol ring therapy for pelvic endometriosis, in particular deeply infiltrating endometriosis via openalex
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Cited by (50)
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- The role of pharmacotherapy in the treatment of endometriosis: an update 2025
- Androgen Signaling in Uterine Diseases: New Insights and New Targets 2022
- Medical treatments of endometriosis: a review 2022
- Hormonal drugs for the treatment of endometriosis 2022
- Hormonal Therapy in Endometriosis and Adenomyosis: Danazol, Aromatase Inhibitors 2022
- Medical management of endometriosis 2021
- Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure 2020
- The role of pharmacotherapy in the treatment of endometriosis across the lifespan 2020
- Endometriosis Pain Management: a Review 2020
- Endometriosis Treatment 2020
- Long-Term Vaginal Danazol Treatment in Fertile Age Women with Adenomyosis 2017
- Medical treatment of endometriosis: an update 2017
- Hormonal therapy for endometriosis: from molecular research to bedside 2016
- Identifying biomarkers for non-invasive diagnosis of endometriosis 2016
- THE ROLE OF AROMATASE IN THE DEVELOPMENT OF ENDOMETRIOSIS 2016
- Adenomyosis: a systematic review of medical treatment 2016
- Response to “A new approach to the management of ovarian endometrioma to prevent tissue damage and recurrence” 2016
- Comparative study of vaginal danazol vs diphereline (a synthetic GnRH agonist) in the control of bleeding during hysteroscopic myomectomy in women with abnormal uterine bleeding: a randomized controlled clinical trial 2015
- Vaginally Administered Danazol: An Overlooked Option in the Treatment of Rectovaginal Endometriosis? 2015
- Safety of medical treatments for endometriosis 2015
- Emerging therapy for endometriosis 2015
- Systematic review of endometriosis pain assessment: how to choose a scale? 2014
- Medikamentöse Therapie der Endometriose 2014
- Treatment of pelvic pain associated with endometriosis: a committee opinion 2014
- Medikamentöse Therapie der Endometriose 2013
- Hormonal strategy for the primary or secondary treatment of endometriosis 2012
- The practicability and surgeons’ subjective experiences with vaginal danazol before an operative hysteroscopy 2012
- Methodological Issues in Preclinical Mouse Efficacy Studies of Adenomyosis 2012
- Innovations in conservative endometriosis treatment: an updated review. 2011
- Medikamentöse Therapie der chronischen Endometriose 2011
- Endometrioza w wieku przed- i oko³omenopauzalnym - jak leczyæ? Endometriosis in pre- and perimenopausal age - how to treat? 2011
- Endometriosis in pre- and perimenopausal age – how to treat? 2011
- Chronische Endometriose: medikamentöse Therapie 2010
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- Interventions for women with endometrioma prior to assisted reproductive technology 2010
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- Evaluation of the efficacy of a danazol-loaded intrauterine contraceptive device on adenomyosis in an ICR mouse model 2008
- Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age 2008
- Tratamiento de la adenomiosis 2007
- Physical therapy in the management of women with chronic pelvic pain 2007
- Efficacy of vaginal danazol treatment in women with recurrent deeply infiltrating endometriosis 2007
- Local drug release systems in endometriosis 2007
Source provenance
- europepmc
- last seen: 2026-08-14T06:11:53.302379+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:12:32.173627+00:00
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