Hormonal drugs for the treatment of endometriosis

Tommaso Capezzuoli; Margherita Rossi; Filippo La Torre; Francesco La Torre; Silvia Vannuccini; Felice Petraglia

doi:10.1016/j.coph.2022.102311

Hormonal drugs for the treatment of endometriosis

Tommaso Capezzuoli, Margherita Rossi, Filippo La Torre, Francesco La Torre, Silvia Vannuccini, Felice Petraglia

Current opinion in pharmacology · 2022 · vol. 67 , pp. 102311 · doi:10.1016/j.coph.2022.102311 · PMID:36279764 · W4306972495

review OA: green CC0 ⤵ 30 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review examines hormonal treatments for endometriosis, including progestins, oral contraceptives, and GnRH agonists, and discusses their efficacy and side effects.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Female Female Female Female Female Female Female Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (55)

A danazol-loaded intrauterine device decreases dysmenorrhea, pelvic pain, and dyspareunia associated with endometriosis via openalex
Clinical diagnosis of endometriosis: a call to action via openalex
Dienogest and deep infiltrating endometriosis: The remission of symptoms is not related to endometriosis nodule remission via openalex
Dienogest or Norethindrone acetate for the treatment of ovarian endometriomas: Can we avoid surgery? via openalex
Dienogest therapy during the early stages of recurrence of endometrioma might be an alternative therapeutic option to avoid repeat surgeries via openalex
Dienogest vs GnRH agonists as postoperative therapy after laparoscopic eradication of deep infiltrating endometriosis with bowel and parametrial surgery: a randomized controlled trial via openalex
Efficacy and acceptability of long-term norethindrone acetate for the treatment of rectovaginal endometriosis via openalex
Efficacy of vaginal danazol treatment in women with recurrent deeply infiltrating endometriosis via openalex
From pathogenesis to clinical practice: Emerging medical treatments for endometriosis via openalex
Gonadotrophin-releasing hormone analogues for pain associated with endometriosis via openalex
Hormonal therapy for endometriosis: from molecular research to bedside via openalex
Is dienogest the best medical treatment for ovarian endometriomas? Results of a multicentric case control study via openalex
Levonorgestrel-Releasing Intrauterine System for the Treatment of Endometriosis: Biological and Clinical Evidence via openalex
Long-term hormonal treatment reduces repetitive surgery for endometriosis recurrence via openalex
Long-term medical management of endometriosis with dienogest and with a gonadotropin-releasing hormone agonist and add-back hormone therapy via openalex
Long-Term Outcomes of Elagolix in Women With Endometriosis via openalex
Long term treatment of endometriosis associated pain (EAP) with linzagolix: efficacy and safety after 12 months of treatment via openalex
Long-term treatment of endometriosis-related pain among women seeking hormonal contraception via openalex
Long-term treatment of endometriosis with dienogest: retrospective analysis of efficacy and safety in clinical practice via openalex
Medical treatment of ovarian endometriomas: a prospective evaluation of the effect of dienogest on ovarian reserve, cyst diameter, and associated pain via openalex
Norethindrone acetate or dienogest for the treatment of symptomatic endometriosis: a before and after study via openalex
Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind, studies (SPIRIT 1 and 2) via openalex
Oral and depot progestin therapy for endometriosis: towards a personalized medicine via openalex
Oral contraceptives for pain associated with endometriosis via openalex
Partial suppression of estradiol: a new strategy in endometriosis management? via openalex
Postoperative maintenance levonorgestrel-releasing intrauterine system and endometrioma recurrence: a randomized controlled study via openalex
Progestagens and anti-progestagens for pain associated with endometriosis via openalex
Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure via openalex
Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills via openalex
Prolonged cyclical and continuous regimens of dydrogesterone are effective for reducing chronic pelvic pain in women with endometriosis: results of the ORCHIDEA study via openalex
Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment via openalex
Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, reduces endometriosis-associated pain in a dose–response manner: a randomized, double-blind, placebo-controlled study via openalex
Rethinking mechanisms, diagnosis and management of endometriosis via openalex
Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist via openalex
Treatment of endometriosis-associated pain with linzagolix, an oral gonadotropin-releasing hormone–antagonist: a randomized clinical trial via openalex
Use of a progestogen only preparation containing desogestrel in the treatment of recurrent pelvic pain after conservative surgery for endometriosis via openalex
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W2562313672 via openalex
W2987085499 via openalex
W3043141560 via openalex
W3048062679 via openalex
W2166744769 via openalex
W3165294846 via openalex
W3194419458 via openalex
W4200280437 via openalex
W4200472726 via openalex
W4214754424 via openalex
W4234160457 via openalex

Cited by (30)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-06-02T00:34:43.480775+00:00

License: CC0 · commercial use OK

[1] A danazol-loaded intrauterine device decreases dysmenorrhea, pelvic pain, and dyspareunia associated with endometriosis via openalex

[2] Clinical diagnosis of endometriosis: a call to action via openalex

[3] Dienogest and deep infiltrating endometriosis: The remission of symptoms is not related to endometriosis nodule remission via openalex

[4] Dienogest or Norethindrone acetate for the treatment of ovarian endometriomas: Can we avoid surgery? via openalex

[5] Dienogest therapy during the early stages of recurrence of endometrioma might be an alternative therapeutic option to avoid repeat surgeries via openalex

[6] Dienogest vs GnRH agonists as postoperative therapy after laparoscopic eradication of deep infiltrating endometriosis with bowel and parametrial surgery: a randomized controlled trial via openalex

[7] Efficacy and acceptability of long-term norethindrone acetate for the treatment of rectovaginal endometriosis via openalex

[8] Efficacy of vaginal danazol treatment in women with recurrent deeply infiltrating endometriosis via openalex

[9] From pathogenesis to clinical practice: Emerging medical treatments for endometriosis via openalex

[10] Gonadotrophin-releasing hormone analogues for pain associated with endometriosis via openalex

[11] Hormonal therapy for endometriosis: from molecular research to bedside via openalex

[12] Is dienogest the best medical treatment for ovarian endometriomas? Results of a multicentric case control study via openalex

[13] Levonorgestrel-Releasing Intrauterine System for the Treatment of Endometriosis: Biological and Clinical Evidence via openalex

[14] Long-term hormonal treatment reduces repetitive surgery for endometriosis recurrence via openalex

[15] Long-term medical management of endometriosis with dienogest and with a gonadotropin-releasing hormone agonist and add-back hormone therapy via openalex

[16] Long-Term Outcomes of Elagolix in Women With Endometriosis via openalex

[17] Long term treatment of endometriosis associated pain (EAP) with linzagolix: efficacy and safety after 12 months of treatment via openalex

[18] Long-term treatment of endometriosis-related pain among women seeking hormonal contraception via openalex

[19] Long-term treatment of endometriosis with dienogest: retrospective analysis of efficacy and safety in clinical practice via openalex

[20] Medical treatment of ovarian endometriomas: a prospective evaluation of the effect of dienogest on ovarian reserve, cyst diameter, and associated pain via openalex

[21] Norethindrone acetate or dienogest for the treatment of symptomatic endometriosis: a before and after study via openalex

[22] Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind, studies (SPIRIT 1 and 2) via openalex

[23] Oral and depot progestin therapy for endometriosis: towards a personalized medicine via openalex

[24] Oral contraceptives for pain associated with endometriosis via openalex

[25] Partial suppression of estradiol: a new strategy in endometriosis management? via openalex

[26] Postoperative maintenance levonorgestrel-releasing intrauterine system and endometrioma recurrence: a randomized controlled study via openalex

[27] Progestagens and anti-progestagens for pain associated with endometriosis via openalex

[28] Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure via openalex

[29] Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills via openalex

[30] Prolonged cyclical and continuous regimens of dydrogesterone are effective for reducing chronic pelvic pain in women with endometriosis: results of the ORCHIDEA study via openalex

[31] Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment via openalex

[32] Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, reduces endometriosis-associated pain in a dose–response manner: a randomized, double-blind, placebo-controlled study via openalex

[33] Rethinking mechanisms, diagnosis and management of endometriosis via openalex

[34] Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist via openalex

[35] Treatment of endometriosis-associated pain with linzagolix, an oral gonadotropin-releasing hormone–antagonist: a randomized clinical trial via openalex

[36] Use of a progestogen only preparation containing desogestrel in the treatment of recurrent pelvic pain after conservative surgery for endometriosis via openalex

[37] W4241541695 via openalex

[38] W2126339803 via openalex

[39] W4280508661 via openalex

[40] W6632805293 via openalex

[41] W6638359506 via openalex

[42] W6804990833 via openalex

[43] W2899183806 via openalex

[44] W6837363199 via openalex

[45] W2562313672 via openalex

[46] W2987085499 via openalex

[47] W3043141560 via openalex

[48] W3048062679 via openalex

[49] W2166744769 via openalex

[50] W3165294846 via openalex

[51] W3194419458 via openalex

[52] W4200280437 via openalex

[53] W4200472726 via openalex

[54] W4214754424 via openalex

[55] W4234160457 via openalex