Use of a progestogen only preparation containing desogestrel in the treatment of recurrent pelvic pain after conservative surgery for endometriosis

Sandro Razzi, Razzi S, Stefano Luisi, Ferretti C, Caterina Ferretti, Calonaci F, Francesco Calonaci, Massimo Gabbanini, Gabbanini M, Massimo Mazzini, Mazzini M, Felice Petraglia
European journal of obstetrics, gynecology, and reproductive biology · 2006 · vol. 135(2) , pp. 188–190 · doi:10.1016/j.ejogrb.2006.08.002 · PMID:16963174 · W2140803998
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This paper examined the effectiveness of a desogestrel-only progestogen preparation in treating recurrent pelvic pain following conservative surgery for endometriosis.

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Abstract

ObjectiveTo assess the effect of a new progestin progestogen only pill (desogestrel) versus an oral contraceptive in the treatment of recurrent endometriosis.Study designA randomized prospective clinical study. A group of women with endometriosis (n=40) who showed recurrent dysmenorrhea and/or pelvic pain after conservative surgery, and did not desire a pregnancy. Continuous treatment for 6 months with desogestrel (75 microg/d) (n=20) versus a combined oral contraceptive (ethinyl estradiol 20 microg plus desogestrel 150 microg) (n=20) was performed.ResultsA significant improvement of both pelvic pain and dysmenorrhea was observed following each type of treatment (P<0.001). The use of desogestrel progestogen only pill was associated with a breakthrough bleeding in 20% patients, while a significant body weight increase was observed in 15% after oral contraceptive.ConclusionsBoth desogestrel and an oral estro-progestinic were effective, safe and low cost therapy of pain symptoms after endoscopic surgery for endometriosis, the former showing an impact on breakthrough bleeding, the later an incidence on body weight increase.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Desogestrel Endometriosis Ethinyl Estradiol Pelvic Pain Progestins Adult Desogestrel Endometriosis Endometriosis Endometriosis Ethinyl Estradiol Female Humans Metrorrhagia Metrorrhagia Metrorrhagia Pelvic Pain Progestins Weight Gain Weight Gain

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (49)

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