Pelvic Pain and Quality of Life of Women With Endometriosis During Quadriphasic Estradiol Valerate/Dienogest Oral Contraceptive: A Patient-Preference Prospective 24-Week Pilot Study

Giovanni Grandi, Anjeza Xholli, Antonella Napolitano, Federica Palma, Angelo Cagnacci
Reproductive sciences (Thousand Oaks, Calif.) · 2014 · vol. 22(5) , pp. 626–632 · doi:10.1177/1933719114556488 · PMID:25394646 · W2167096921
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Quadriphasic estradiol valerate/dienogest treatment significantly reduced pelvic pain and improved quality of life in women with endometriosis compared to NSAIDs over 24 weeks.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This 24-week patient-preference prospective observational pilot study enrolled 40 women with endometriosis and menstrual pain, comparing a quadriphasic oral estradiol valerate/dienogest regimen (E2V/DNG) to NSAID use-only-with-pain ketoprofene. Menstrual and intermenstrual pain and dyspareunia were measured on 10-cm visual analogue scales, and health-related quality of life was assessed with SF-36, with 34 completing the study (19 E2V/DNG, 15 NSAID). After 24 weeks, E2V/DNG reduced menstrual pain VAS by 61% and also reduced intermenstrual pain and dyspareunia in subgroup analyses, with improved SF-36 scores, whereas the NSAID group showed no significant symptom or quality-of-life changes; the authors note the study is a small pilot. This paper is centrally about endometriosis — it evaluates pelvic pain and quality of life in endometriosis patients treated with quadriphasic estradiol valerate/dienogest.

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Condition tags

mesh:D004412mesh:D004715mesh:D017699endometriosis

MeSH descriptors

Contraceptives, Oral, Hormonal Dysmenorrhea Endometriosis Estradiol Nandrolone Patient Preference Pelvic Pain Quality of Life Adult Contraceptives, Oral, Hormonal Contraceptives, Oral, Hormonal Drug Combinations Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometriosis Estradiol Estradiol

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (38)

Cited by (36)

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