Long-term oral contraceptive pills and postoperative pain management after laparoscopic excision of ovarian endometrioma: a randomized controlled trial

Renato Seracchioli, Mohamed Mabrouk, Clarissa Frascà, Frascà C, Manuzzi L, Linda Manuzzi, Luca Savelli, L. Savelli, Stefano Venturoli, Venturoli S
Fertility and sterility · 2009 · vol. 94(2) , pp. 464–471 · doi:10.1016/j.fertnstert.2009.03.083 · PMID:19442968 · W2039313615
article OA: closed CC0 ⤵ 139 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This randomized controlled trial investigated the effect of long-term oral contraceptive pills on postoperative pain management following laparoscopic excision of ovarian endometrioma.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo evaluate postoperative long-term cyclic and continuous administration of combined oral contraceptive (OC) pills in preventing endometriosis-related pain recurrence.DesignProspective, randomized, controlled trial.SettingTertiary care university hospital.Patient(s)Three hundred eleven women who underwent laparoscopic excision for symptomatic ovarian endometrioma.Intervention(s)Patients were randomly divided into three groups: nonuser group receiving no therapy, and cyclic user group and continuous user group receiving low-dose, monophasic OC pills for 24 months in either cyclic or continuous administration.Main outcome measure(s)Presence and intensity of dysmenorrhea, dyspareunia, and chronic pelvic pain were assessed by a 10-point visual analogue scale (VAS) at 6, 12, 18, and 24 months postoperatively.Result(s)A significant reduction in recurrence rate and VAS scores for dysmenorrhea was evident in the continuous users versus the other groups at 6 months, and in cyclic users versus nonusers at 18 months postoperatively. No significant differences in recurrence rate and VAS scores for dyspareunia and chronic pelvic pain were demonstrated among the groups. The increase of VAS scores from 6-24 months during the study period for dysmenorrhea, dyspareunia, and chronic pelvic pain was significantly higher in nonusers than in the other groups.Conclusion(s)Long-term postoperative use of OC pills can reduce the frequency and the severity of recurrent endometriosis-related dysmenorrhea.

My notes (saved in your browser only)

Condition tags

dysmenorrheadyspareuniaendometriosisendometrioma

MeSH descriptors

Contraceptives, Oral Endometriosis Laparoscopy Ovarian Diseases Postoperative Pain Postoperative Pain Adult Chronic Disease Contraceptives, Oral Contraceptives, Oral Disease-Free Survival Dysmenorrhea Dysmenorrhea Dysmenorrhea Dyspareunia Dyspareunia Dyspareunia Endometriosis Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (22)

Cited by (50)

Source provenance

europepmc
last seen: 2026-08-02T06:10:09.037253+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:14:05.573375+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0 · commercial use OK