Age at surgery and recurrence of ovarian endometrioma after conservative surgery: a meta-analysis including 3125 patients

Fang Yang, Baoqin Liu, Lin Xu, Hong Liu
Archives of gynecology and obstetrics · 2020 · vol. 302(1) , pp. 23–30 · doi:10.1007/s00404-020-05586-3 · PMID:32430756 · W3028165541
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This meta-analysis of 3125 patients found that the recurrence rate of ovarian endometrioma after conservative surgery decreased with increasing age, suggesting younger age is a high-risk factor.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This meta-analysis evaluated whether age at surgery is associated with recurrence of ovarian endometrioma after conservative surgery, using studies identified from PubMed, Embase, and the Cochrane Library through October 2019. Across 10 studies totaling 3125 patients, the pooled analysis found that the recurrence rate decreased as age increased (RR = 0.93, 95% CI 0.91–0.95), with no evidence of publication bias based on Begg’s funnel plot and Egger’s regression; subgroup analyses also examined cut-offs at <35 and ≥35 years. The included evidence comprised both retrospective and prospective designs and assessed recurrence by ultrasound at least 6 months after surgery, and while study quality was generally high (NOS 6–8), the paper does not describe whether all relevant confounders were uniformly controlled across studies. This paper is centrally about endometriosis — it specifically analyzes how patient age at conservative surgery relates to ovarian endometrioma recurrence.

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Abstract

PURPOSE: To evaluate the association between age at surgery and recurrence rate of endometrioma. Data sources PubMed, Embase, and the Cochrane Library were searched up to October 2019. METHODS: We determined the pooled relative risk (RR) and 95% confidence intervals (CIs) to assess the relationship between age at surgery and the recurrence rate of endometrioma after surgery. Begg's funnel plot and Egger's linear regression was used to assess any publication bias. RESULTS: A total of 3125 patients from 10 studies were finally enrolled in this meta-analysis. The recurrence rate decreased with increasing age (RR = 0.93, 95% CI = 0.91-0.95, P = 0.451). Subgroup analysis demonstrated that the pooled RR was 0.926 (95% CI 0.906-0.947, P < 0.001) for a cut-off < 35, and 0.886 (95% CI 0.775-1.040, P = 0.14) for a cut-off ≥ 35. Begg's funnel plot and Egger's linear regression test showed no evidence of publication bias. CONCLUSION: This meta-analysis suggested that younger age might be a high-risk factor for the recurrence of ovarian endometrioma after conservative surgery.

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Condition tags

mesh:D004412mesh:D004715endometrioma

MeSH descriptors

Endometriosis Ovarian Diseases Adult Age Factors Dysmenorrhea Endometriosis Endometriosis Female Humans Ovarian Diseases Ovarian Diseases Recurrence Risk Factors

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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