The problem of recurrence of ovarian endometriomas

V.B. Tskhay, Э. К. Гребенникова, Ju. N. Skuratova
In: Medical Herald of the South of Russia · 2025 · vol. 16(1) , pp. 5–13 · doi:10.21886/2219-8075-2025-16-1-5-13 · W4408920491
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review analyzes literature on ovarian endometrioma recurrence, detailing noninvasive markers, diagnostic models, and drug therapy effectiveness for prevention after surgery.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This paper is a literature review (2016–2023 sources) on recurrence of ovarian endometriomas after surgery, focusing on risk mechanisms, prognostic factors, noninvasive diagnostic/biomarker approaches, and the effectiveness of postoperative medical therapy. It summarizes theories for recurrence (residual microscopic disease, missed lesions, de novo disease, or combinations), reports high recurrence rates over time, and notes that endometrioma recurrence can remain frequent even with hormonal treatment, while cystectomy (“stripping”) is generally associated with lower recurrence than more tissue-sparing but higher-recurrence approaches. The review also discusses links between endometriomas and infertility via effects on ovarian reserve (e.g., vascular compromise, oxidative/inflammatory pathways leading to fibrosis) and acknowledges limitations such as incomplete understanding of the infertility mechanisms and ongoing debate about whether endometrioma size versus the condition itself drives ovarian reserve decline. Relevance to endometriosis: the paper is centrally about recurrence of ovarian endometriomas, a specific subtype of endometriosis.

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Abstract

Objective : this article is a scientific review of the literature devoted to the important problem of ovarian endometrioma recurrence in the postoperative period. The data were analyzed based on foreign and domestic sources e-Library, Springer Nature, Wiley Journals, PubMed for 2016–2023 using the following keywords: «endometrioma», «risk factors», «recurrence», «prediction», «biomarkers». In the process of literature review, a significant relationship between infertility and ovarian endometriosis has been established, but all mechanisms in the occurrence of infertility in ovarian endometriomas remain incompletely understood. Noninvasive markers involved in the pathogenesis of the disease - apoptosis, angiogenesis, adhesion, as well as the possibilities of the diagnostic model of noninvasive diagnosis of endometriomas in the postoperative period are described in detail. The data on the effectiveness of drug therapy, as a way of preventing postoperative recurrence of the disease are highlighted and summarized.

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Condition tags

endometriosisendometriomainfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (53)

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