Evaluation of BCL6 and SIRT1 as Non-Invasive Diagnostic Markers of Endometriosis

Alison M Sansone, Brooke V Hisrich, R Brandt Young, William F Abel, Zachary Bowens, Bailey B Blair, Bailey Brenna Blair, Avery Funkhouser, David P Schammel, Lisa J Green, Bruce A Lessey, Anna V. Blenda
Current issues in molecular biology · 2021 · vol. 43(3) , pp. 1350–1360 · doi:10.3390/cimb43030096 · PMID:34698105 · W3201827650
review OA: gold CC0 ⤵ 17 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study measured BCL6 and SIRT1 levels in various bodily fluids from women with and without endometriosis, finding significantly elevated serum SIRT1 in advanced stages of the disease.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

(1) Background: Endometriosis is characterized by the presence of endometrial glands and stroma outside of the uterus and is often associated with severe pelvic pain and infertility. Our study explored the utilization of B-Cell Lymphoma 6 (BCL6) and Sirtuin 1 (SIRT1) as potential biomarkers in serum, plasma, urine, and cervical mucus for a non-invasive diagnostic test for endometriosis. BCL6 was chosen based on its previously reported elevated expression in endometrial biopsies, and SIRT1 is co-expressed and upregulated in the endometrium of women with endometriosis. (2) Methods: BCL6 and SIRT1 levels were measured using enzyme-linked immunoassay (ELISA) in samples from 20 women with endometriosis (ten with stages I/II and ten with stages III/IV) and ten women without endometriosis. (3) Results: Levels of SIRT1 in sera showed a statistically significant elevation in advanced stages III/IV compared to controls and stages I/II. No significant differences were found in other bodily fluids for SIRT1 or any bodily fluids tested for BCL6. (4) Conclusions: These results suggest some potential of SIRT1 expression within serum as a predictor of advanced asymptomatic stages of endometriosis. Using immunohistochemistry (IHC) staining and H-SCORE values for the elevated BCL6 (and potentially SIRT1) levels in endometrial biopsy samples seems to have higher diagnostic potential based on the previously published studies.

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Biomarkers Endometriosis Endometriosis Proto-Oncogene Proteins c-bcl-6 Sirtuin 1 Adolescent Adult Cytokines Cytokines Endometriosis Endometriosis Endometrium Endometrium Endometrium Enzyme-Linked Immunosorbent Assay Female Humans Inflammation Mediators Inflammation Mediators Prognosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (48)

Cited by (17)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:24:14.728497+00:00
License: CC0 · commercial use OK