Levels of oxidative stress and apoptosis-related biomarkers in endometriosis

Dilara Ülger Özbek, Savaş Karakuş, Sevtap Bakır
In: Cukurova Medical Journal · 2023 · vol. 48(2) , pp. 480–488 · doi:10.17826/cumj.1247227 · W4383763426
article OA: diamond CC0 ⤵ 2 in-corpus citations
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found lower M30 and higher ADMA levels in endometriosis patients compared to controls, suggesting reduced apoptosis and increased oxidative stress.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-23 · read from full text ⓘ

This study measured oxidative stress and apoptosis-related biomarkers in individuals with endometriosis, assessing levels of markers including MDA and ADMA and an apoptosis-related marker set involving M30, using biochemical assays. The authors report altered biomarker levels in endometriosis compared with reference values, supporting an association between oxidative stress and apoptosis processes in the condition. A key limitation is that the work does not establish causal direction between biomarker changes and endometriosis pathophysiology. This paper is centrally about endometriosis — it focuses on oxidative stress and apoptosis-related biomarkers (e.g., MDA, ADMA, and M30) in endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Purpose: In this study, the apoptosis marker M30, the oxidative stress markers malondialdehyde, (MDA) and asymmetric dimethyl arginine (ADMA) have been studied in the context of endometriosis. Materials and Methods: This prospective case-control study comprises 31 patients diagnosed with endometriosis and 31 controls. ADMA and M30 levels in blood serum were measured by the enzyme-linked immunosorbent assay (ELISA) method, and MDA levels were measured by the spectrophotometric method. In addition, some biochemical parameters and cancer antigen-125 (CA-125) levels were also measured. Results: M30 levels were statistically lower in endometriosis patients (271.5 IU/L) than in controls (371.3 IU/L). ADMA levels were higher in endometriosis patients (19.3 ng/L) compared to controls (12.7 ng/L). CA-125 levels were statistically higher in the endometriosis patients (65.1 U/mL) compared to the controls (19.0 U/mL). There was no significant difference between the two groups in MDA levels. The results regarding dyspareunia, pelvic pain, AST, and ALP were statistically significant. Conclusion: In our study, decreased M30 levels in the patient group were associated with reduced apoptosis in endometriosis. ADMA levels, elevated with the increase of oxidative stress, were higher in the patients. MDA levels, an indicator of increased oxidative stress, were also higher in the patient group. This study constitutes the first data regarding endometriosis patients' ADMA, M30, and MDA levels.
Full text 1,903 characters · extracted from oa-doi-fallback · 2 sections · click to expand

Abstract

Keywords Apoptosis, ADMA, Endometriosis, MDA, M30 Supporting Institution Project Number Thanks

References

- Kao LGL, Giudice L. Endometriosis. Lancet. 2004;364:1789-99. - Stratton P, Winkel C, Premkumar A, Chow C, Wilson J, Hearns-Stokes R et al. Diagnostic accuracy of laparoscopy, magnetic resonance imaging, and histopathologic examination for the detection of endometriosis. Fertil Steril. 2003;79:1078-85. - Brosens I, Puttemans P, Campo R, Gordts S, Brosens J. Non-invasive methods of diagnosis of endometriosis. Curr Opin Obstet Gynecol. 2003;15:519-22. - Sampson JA. Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol. 1927;14:422-69. - Chantalat E, Valera MC, Vaysse C, Noirrit E, Rusidze M, Weyl A et al. Estrogen receptors and endometriosis. Int J Mol Sci. 2020;21:2815. - Patel BG, Rudnicki M, Yu J, Shu Y, Taylor RN. Progesterone resistance in endometriosis: origins, consequences and interventions. Acta Obstet Gynecol Scand. 2017;96:623-32. - Yang WC, Chen HW, Au HK, Chang CW, Huang CT, Yen YH et al. Serum and endometrial markers. Best Pract Res Clin Obstet Gynaecol. 2004;18:305-18. - Gonçalves G, Camargo-Kosugi C, Bonetti T, Invitti A, Girão M, Silva I et al. p27 kip1 overexpression regulates VEGF expression, cell proliferation and apoptosis in cell culture from eutopic endometrium of women with endometriosis. Apoptosis. 2015;20:327-35. - Gaben AM, Saucier Cc, Bedin M, Redeuilh Gr, Mester J. Mitogenic activity of estrogens in human breast cancer cells does not rely on direct induction of mitogen-activated protein kinase/extracellularly regulated kinase or phosphatidylinositol 3-kinase. Mol Endocrinol. 2004;18:2700-13. - Yilmaz BD, Bulun SE. Endometriosis and nuclear receptors. Hum Reprod Update. 2019;25:473-85.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisdyspareunia

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (38)

Cited by (2)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK