Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study

Kasapoglu I, Isil Kasapoglu, Işıl Kasapoğlu, Ata B, Baris Ata, Barış Ata, Ozlem Uyaniklar, Özlem Özgün Uyanıklar, Ayşe Seyhan, Ayse Seyhan, Adnan Orhan, Sule Yildiz Oguz, Şule Yıldız, Yildiz Oguz S, Gürkan Uncu, Gurkan Uncu, Uncu G
Fertility and sterility · 2018 · vol. 110(1) , pp. 122–127 · doi:10.1016/j.fertnstert.2018.03.015 · PMID:29935810 · W2808892623
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This study prospectively followed women with endometriomas to assess the impact of this condition on ovarian reserve over time.

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Abstract

ObjectiveTo evaluate whether endometrioma is associated with a progressive decline in ovarian reserve, and to compare the rate of decline with natural decline in ovarian reserve.DesignProspective, observational study.SettingTertiary university hospital, endometriosis clinic.Patient(s)Forty women with endometrioma and 40 age-matched healthy controls.Intervention(s)Women with endometriomas who did not need hormonal/surgical treatment at the time of recruitment and were expectantly managed. Controls were age-matched, healthy women. All participants underwent serum antimüllerian hormone (AMH) testing twice, 6 months apart. Sexually active patients with endometrioma also underwent antral follicle count.Main outcome measure(s)Change in serum AMH levels.Result(s)Median (25th-75th percentile) serum AMH level at recruitment was 2.83 (0.70-4.96) ng/mL in the endometrioma group and 4.42 (2.26-5.57) ng/mL in the control group. The median percent decline in serum AMH level was 26.4% (11.36%-55.41%) in the endometrioma group and 7.4% (-11.98%, 29.33%) in the control groups. Twenty-two women with endometrioma who had antral follicle count (AFC) had median AFC of 10 (8-12) at recruitment and 8 (6.3-10) at 6 months.Conclusion(s)Women with endometrioma experience a progressive decline in serum AMH levels, which is faster than that in healthy women.Clinical trial registration numberNCT02438735.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Infertility, Female Ovarian Reserve Ovary Adult Anti-Mullerian Hormone Anti-Mullerian Hormone Biomarkers Biomarkers Case-Control Studies Disease Progression Down-Regulation Endometriosis Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Infertility, Female

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References (32)

Cited by (50)

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