Association of endometriosis-related infertility with age at menopause

Toshiyuki Yasui, Yasui T, Kunihiko Hayashi, Mizunuma H, Hideki Mizunuma, Kubota T, Toshiro Kubota, Takeshi Aso, Aso T, Takeshi Asô, Yasuhiro Matsumura, Matsumura Y, Jung‐Su Lee, Lee JS, Jung-Su Lee, Suzuki S, Shosuke Suzuki
Maturitas · 2011 · vol. 69(3) , pp. 279–283 · doi:10.1016/j.maturitas.2011.04.009 · PMID:21605953 · W2119331560
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This study investigated the relationship between endometriosis-related infertility and age at menopause.

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Abstract

ObjectiveThe influence of past history of infertility, which is closely associated with reproductive factors, on menopause has not been clarified. The purpose of this study was to clarify the association of reproductive factors, including past history of infertility, with menopause in Japanese women.Study designThis study was a cross-sectional analysis of the Japan Nurses' Health Study (JNHS) baseline survey. The JNHS is a nationwide prospective cohort study on the health of Japanese women, and the baseline survey was conducted between 2001 and 2007.Main outcome measureWe analyzed data for 24,153 pre- and postmenopausal women who were enrolled in the JNHS at the ages 40-59 years. The main outcome measure was menopause.ResultsReproductive factors influencing the onset of natural menopause were past history of infertility [relative risk (RR) (age-adjusted odds ratio and 95% confidence interval): 1.28 (1.10-1.48)], past history of endometriosis: 1.32 (1.07-1.64), age at menarche: 0.919 (0.886-0.953) and number of pregnancies: 0.943 (0.911-0.976). Endometriosis as the cause of infertility was significantly associated with earlier onset of menopause (3.43 [2.17-5.44]) after adjustment for age. The strong association of past history of infertility related to endometriosis was still significant after multivariate adjustment.ConclusionMenopause in women who have a past history of infertility, especially in those who have suffered from endometriosis, is significantly earlier than that in women without such a history.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Menopause Adult Age Factors Endometriosis Female Gravidity Health Surveys Humans Infertility, Female Japan Menarche Middle Aged Pregnancy Prospective Studies

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References (34)

Cited by (22)

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