at menopause, and impact reproductive health: a UK Biobank study

Katherine S. Ruth, Robin N. Beaumont, Jessica Tyrrell, Samuel E. Jones, Marcus A. Tuke, Andrew R. Wood, Rachel M. Freathy, Michael N. Weedon, Timothy M. Frayling, Anna Murray
2015 · W2474350895
article OA: closed CC0 Metadata only
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

The FSHB promoter polymorphism rs10835638 is associated with longer menstrual cycles, later menopause, reduced fertility, and protection against endometriosis.

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Abstract

Study question: How does a genetic variant altering follicle stimulating hormone (FSH) levels, which we identified as associated with length of menstrual cycle, more widely impact reproductive health? Summary answer: The T allele of the FSHB promoter polymorphism (rs10835638) results in longer menstrual cycles and later menopause and, while having detrimental effects on fertility, is protective against endometriosis.

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endometriosis

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