Aktuelle Aspekte der endokrinen Therapie der Endometriose und der Adenomyose

Zusammenfassung Neben der kontrollierten, rechtzeitigen und indizierten Präzisionschirurgie ist die medikamentöse Therapie der Endometriose, insbesondere auch als Langzeittherapie, von besonderer Bedeutung. Die Behandlung sollte möglichst zielgenau und nebenwirkungsarm sein. Es gibt inzwischen eine Vielzahl von Strategien, um der Patientin Linderung zu verschaffen, jedoch ist bei einer steroidhormonabhängigen Erkrankung die Hormontherapie die Therapie der Wahl. Die wichtigen Pharmaka, wie die oralen Kontrazeptiva, die Gestagene und die neuen oralen GnRH(„gonadotropin-releasing hormone“)-Antagonisten, stehen hier im Vordergrund und sollen deshalb auf Basis der aktuellen Studienlage detailliert dargestellt werden. Abstract In addition to the controlled, timely and indicated precision surgery, the medicinal treatment of endometriosis, particularly also as long-term treatment, is of utmost importance. The treatment should be as acurately targeted as possible and with few side effects. In the meantime, there are many strategies to achieve relief for patients, but hormonal therapy is the treatment of choice in the case of steroid hormone-dependent disease. The important drugs, such as oral contraceptives, the progestins and the new oral gonadotropin-releasing hormone (GnRH) antagonists, are prioritized and are presented in detail based on the current study situation. Similar content being viewed by others Literatur Reis FM, Petraglia F, Taylor RN (2013) Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis. Hum Reprod Update 19(4):406–418. https://doi.org/10.1093/humupd/dmt010 (Epub 2013 Mar 28. PMID: 23539633; PMCID: PMC3682670) Vercellini P, Buggio L, Berlanda N, Barbara G, Somigliana E, Bosari S (2016) Estrogen-progestins and progestins for the management of endometriosis. Fertil Steril 106(7):1552–1571.e2. https://doi.org/10.1016/j.fertnstert.2016.10.022 (Epub 2016 Nov 4. 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Ebert, R. Felberbaum und W. Küpker geben an, dass kein Interessenkonflikt besteht. Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Additional information QR-Code scannen & Beitrag online lesen Rights and permissions About this article Cite this article Ebert, A.D., Felberbaum, R. & Küpker, W. Aktuelle Aspekte der endokrinen Therapie der Endometriose und der Adenomyose. Gynäkologische Endokrinologie 21, 194–200 (2023). https://doi.org/10.1007/s10304-023-00524-3 Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s10304-023-00524-3