Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture

Kaoruko Yamanaka; Bing Xu; Izumi Suganuma; Izumi Kusuki; Shizuka Mita; Yutaka Shimizu; Kiyoshi Mizuguchi; Jo Kitawaki

doi:10.1016/j.fertnstert.2011.11.005

Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture

Kaoruko Yamanaka, Bing Xu, Izumi Suganuma, Izumi Kusuki, Shizuka Mita, Yutaka Shimizu, Kiyoshi Mizuguchi, Jo Kitawaki

Fertility and sterility · 2012 · vol. 97(2) , pp. 477–482 · doi:10.1016/j.fertnstert.2011.11.005 · PMID:22130322 · W2139847184

article OA: closed CC0 ⤵ 85 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Dienogest was found to decrease aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells grown in spheroid culture.

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Condition tags

endometriosis

MeSH descriptors

Aromatase Aromatase Inhibitors Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Dinoprostone Endometriosis Nandrolone Ovarian Diseases Ovary Stromal Cells Adult Aromatase Aromatase Aromatase Inhibitors Cells, Cultured Cyclooxygenase 2 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Dinoprostone DNA

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References (28)

Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system via openalex
Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression via openalex
Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells via openalex
Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial via openalex
Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study via openalex
Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile via openalex
Endometriosis via openalex
ESHRE guideline for the diagnosis and treatment of endometriosis via openalex
Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis. via openalex
High-dose pilot study with the novel progestogen dienogestin patients with endometriosis via openalex
Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis via openalex
New Progestogens via openalex
Progesterone and progestational compounds attenuate tumor necrosis factor alpha–induced interleukin-8 production via nuclear factor kappaB inactivation in endometriotic stromal cells via openalex
The inhibitory effect of dienogest, a synthetic steroid, on the growth of human endometrial stromal cells in vitro via openalex
Tumor necrosis factor-alpha-induced cyclooxygenase-2 overexpression in eutopic endometrium of women with endometriosis by stromal cell culture through nuclear factor-kappaB activation. via openalex
W6723391054 via openalex
W1989696800 via openalex
W1992453495 via openalex
W2001831389 via openalex
W2010311608 via openalex
W2016744320 via openalex
W2022658482 via openalex
W2058312109 via openalex
W2068397002 via openalex
W2101417341 via openalex
W2497131907 via openalex
W4285719527 via openalex
W6605145255 via openalex

Cited by (50)

Source provenance

europepmc: last seen: 2026-06-23T06:15:44.889181+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-05-13T22:16:29.858026+00:00

License: CC0 · commercial use OK

[1] Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system via openalex

[2] Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression via openalex

[3] Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells via openalex

[4] Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial via openalex

[5] Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study via openalex

[6] Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile via openalex

[7] Endometriosis via openalex

[8] ESHRE guideline for the diagnosis and treatment of endometriosis via openalex

[9] Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis. via openalex

[10] High-dose pilot study with the novel progestogen dienogestin patients with endometriosis via openalex

[11] Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis via openalex

[12] New Progestogens via openalex

[13] Progesterone and progestational compounds attenuate tumor necrosis factor alpha–induced interleukin-8 production via nuclear factor kappaB inactivation in endometriotic stromal cells via openalex

[14] The inhibitory effect of dienogest, a synthetic steroid, on the growth of human endometrial stromal cells in vitro via openalex

[15] Tumor necrosis factor-alpha-induced cyclooxygenase-2 overexpression in eutopic endometrium of women with endometriosis by stromal cell culture through nuclear factor-kappaB activation. via openalex

[16] W6723391054 via openalex

[17] W1989696800 via openalex

[18] W1992453495 via openalex

[19] W2001831389 via openalex

[20] W2010311608 via openalex

[21] W2016744320 via openalex

[22] W2022658482 via openalex

[23] W2058312109 via openalex

[24] W2068397002 via openalex

[25] W2101417341 via openalex

[26] W2497131907 via openalex

[27] W4285719527 via openalex

[28] W6605145255 via openalex